Registration Dossier
Registration Dossier
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EC number: 210-351-3 | CAS number: 613-73-0
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- o-phenylenediacetonitrile
- EC Number:
- 210-351-3
- EC Name:
- o-phenylenediacetonitrile
- Cas Number:
- 613-73-0
- Molecular formula:
- C10H8N2
- IUPAC Name:
- 2-[2-(cyanomethyl)phenyl]acetonitrile
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Inoculum or test system:
- activated sludge (adaptation not specified)
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Executive summary:
The Ready Biodegradation in an aerobic aqueous medium of l,2-Phenylendiacetonitrile was tested
by the Closed Bottle Test according guideline92l69tBBC, part C.4-F,.
The test substance in a concentration of approximately 3 mg/l mineral medium was inoculated with
micro - organisms from the efluent of a treatment plant (domestic sewage), filled in BOD bottles
and incubated in the dark at constant temperature (20'C) over 28 days period. Degradation was
followed by analysis of dissolved oxygen. The percentage biodegradation was calculated by dividing
the specific Biological Oxygen Demand by the specific Theoretical Orygen Demand.
No degradation of the test substance u/as measured. The pass level for ready biodegradation
according to the annex fV of the guideline 93/21/EEC (60%) was not reached
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