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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute toxicity studies in rodents.
Author:
D.L.J. Opdyke
Year:
1980
Bibliographic source:
Food and Cosmetics Toxicology
Reference Type:
review article or handbook
Title:
Acute dermal toxicity study of test chemical in rodents.
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials
Reference Type:
other: authoritative database
Title:
Acute Dermal toxicity - Test chemical
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
ChemIDplus

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
The acute dermal toxicity study of the given test chemical was performed in rabbits
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,7-dimethyl-1-octyl acetate
EC Number:
244-034-6
EC Name:
3,7-dimethyl-1-octyl acetate
Cas Number:
20780-49-8
Molecular formula:
C12H24O2
IUPAC Name:
3,7-dimethyl-1-octyl acetate
Details on test material:
- Name of test material (as cited in study report): 3,7-dimethyloctanyl acetate
- Molecular formula : C12H24O2
- Molecular weight : 200.32 g/mol
- Substance type: Organic
- Physical state:Liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 3,7-dimethyloctanyl acetate
- Molecular formula : C12H24O2
- Molecular weight : 200.32 g/mol
- Substance type: Organic
- Physical state:Liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
approximate LD50
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at 5000 mg/kg bw in treated animals.
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute dermal LD50 value was considered to be approximately 5000 mg/Kg bw, when rabbits were treated with the given test chemical by dermal application.
Executive summary:

The acute dermal toxicity study was conducted by using the given test chemical in rabbits at the dose concentration of 5000 mg/kg bw. Animals were observed for mortality. 50% mortality was observed at 5000 mg/kg bw in treated animals. Hence, the acute dermal LD50 value was considered to be approximately 5000 mg/Kg bw, when rabbits were treated with the given test chemical by dermal application.