Registration Dossier
Registration Dossier
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EC number: 203-481-7 | CAS number: 107-31-3
Endpoint summary
Administrative data
Description of key information
The rapid hydrolysis will be the major fate process of the methyl formate under environmentally relevant conditions (pH 7-9). Therefore, this estimate may be of low relevance. Thus, the assessment of the short-term and long-term toxicity of the substance is also based on the available experimental data for the hydrolytic products: formic acid and methanol.
Short-term toxicity to fish
The parent compound methyl formate along with its hydrolysis products formic acid and methanol are with high probability acutely not harmful to fish.
Long-term toxicity to fish
Parent compound (CAS 107-31-3):
Data waiving according to Annex XI of Regulation (EC) No.1907/2006.
Hydrolysis product methanol (CAS 67-56-1):
Key: Based on the available 96-h LC50 of = 15400 mg/L (Lepomis macrochirus, EPA-660/3-75-009; published at Bulletin of Environmental Contamination and Toxicology 37: 615-621, 1986) a NOEC for the long-term toxicity to fish of 154 mg/L was derived (ACR approach, 2021).
Supporting: In early-life-stage bioassay conducted with Oryzias latipes (Gonzales-Doncel et al., 2008), NOECs range between 7900 - 15800 mg/L. Although this in-vitro study was not conducted according to current standard guidelines, the results give a clear indication of the low hazard potential (acute and long-term) of methanol to aquatic organisms
Hydrolysis product formic acid (CAS 64-18-6):
Data waiving according to Annex XI of Regulation (EC) No.1907/2006 and Annex IX, Section 9.1.6, Column 2 of Regulation (EC) No 1907/2006
Short-term toxicity to aquatic invertebrates
The parent compound methyl formate along with its hydrolysis products formic acid and methanol are with high probability acutely not harmful to aquatic invertebrates.
Long-term toxicity to aquatic invertebrates
Parent compound (CAS 107-31-3):Data waiving according to Annex IX Regulation (EC) No 1907/2006.
Hydrolysis product methanol (CAS 67-56-1):
Key: 21 -d NOEC = 224 mg/l (OECD QSAR Toolbox v4.3.1, 2021)
Hydrolysis product formic acid (CAS 64-18-6):
Key: 21 -d NOEC >= 100 mg/L (BASF AG, rep. no.: 51E274/073100, 2007).
Toxicity to aquatic algae and cyanobacteria
The parent compound methyl formate along with its hydrolysis products formic acid and methanol are with high probability acutely not harmful to algae
Toxicity to microorganisms
The inhibition of the degradation activity of activated sludge is not anticipated when the parent compound methyl formate or its hydrolysis products formic acid and methanol are introduced in appropriate low concentrations.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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