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EC number: 204-541-5 | CAS number: 122-40-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- LETTER SUBMITTING NINE ENCLOSED STUDIES ON 2-(PHENYLMETHYLENE) HEPTANAL WITH ATTACHMENTS (SANITIZED)
- Author:
- NTRL
- Year:
- 1 991
- Bibliographic source:
- NTRL REPORT-OTS0535053; NOVEMBER 27, 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The method of procedure is that suggested by Dr. Draize and described in "Appraisal of the Safety of Chemicals in Food. Drugs and Cosmetics” published by the Association of Food and Drug Officials of the United States
- Principles of method if other than guideline:
- An eye study of alpha-Amyl cinnamaldehyde (CAS No: 122-40-7) to determine if the test material produces any irritation when instilled into rabbits' eyes.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-benzylideneheptanal
- EC Number:
- 204-541-5
- EC Name:
- 2-benzylideneheptanal
- Cas Number:
- 122-40-7
- Molecular formula:
- C14H18O
- IUPAC Name:
- 2-benzylideneheptanal
- Test material form:
- liquid
- Details on test material:
- - Name of test material: (2E)-2-(phenylmethylidene)heptanal
- Molecular formula: C14H18O
- Molecular weight: 202.2952 g/mol
- Smiles notation: c1(\C=C(\CCCCC)C=O)ccccc1
- InChl: 1S/C14H18O/c1-2-3-5-10-14(12-15)11-13-8-6-4-7-9-13/h4,6-9,11-12H,2-3,5,10H2,1H3/b14-11-
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: (2E)-2-(phenylmethylidene)heptanal
- Molecular formula: C14H18O
- Molecular weight: 202.2952 g/mol
- Smiles notation: c1(\C=C(\CCCCC)C=O)ccccc1
- InChl: 1S/C14H18O/c1-2-3-5-10-14(12-15)11-13-8-6-4-7-9-13/h4,6-9,11-12H,2-3,5,10H2,1H3/b14-11-
- Substance type: Organic
- Physical state: Liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.1ml
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- Every twenty-four hours for four days and then again on the seventh day.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- TEST SITE
- % coverage: Right eye
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not washed
- Time after start of exposure: 24 hours
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No ocular lesions were observed in treated rabbits.
Any other information on results incl. tables
RABBIT 1:DRAIZE EYE IRRITATION SCORES |
|||||
OCULAR LESIONS |
DAYS AFTER INSTALLATION |
||||
Cornea Grade |
1 |
2 |
3 |
4 |
7 |
(A)Opacity |
0 |
0 |
0 |
0 |
0 |
(B) Area Of Cornea Involved |
0 |
0 |
0 |
0 |
0 |
Score equals |
(0X0X0)=0 |
||||
|
|||||
Iris |
0 |
0 |
0 |
0 |
0 |
Score equals |
(0X5)=0 |
||||
|
|||||
Conjunctivae |
|
|
|
|
|
(A)Redness |
0 |
0 |
0 |
0 |
0 |
(B ) Chemosis |
0 |
0 |
0 |
0 |
0 |
(C) Discharge |
0 |
0 |
0 |
0 |
0 |
Score equal s |
(0+0+0)X0=0 |
|
|
|
|
RABBIT 2:DRAIZE EYE IRRITATION SCORES |
|||||
OCULAR LESIONS |
DAYS AFTER INSTALLATION |
||||
Cornea Grade |
1 |
2 |
3 |
4 |
7 |
(A)Opacity |
0 |
0 |
0 |
0 |
0 |
(B) Area Of Cornea Involved |
0 |
0 |
0 |
0 |
0 |
Score equals |
(0X0X0)=0 |
||||
|
|||||
Iris |
0 |
0 |
0 |
0 |
0 |
Score equals |
(0X5)=0 |
||||
|
|||||
Conjunctivae |
|
|
|
|
|
(A)Redness |
0 |
0 |
0 |
0 |
0 |
(B ) Chemosis |
0 |
0 |
0 |
0 |
0 |
(C) Discharge |
0 |
0 |
0 |
0 |
0 |
Score equals |
(0+0+0)X0=0 |
|
|
|
|
RABBIT 3:DRAIZE EYE IRRITATION SCORES |
|||||
OCULAR LESIONS |
DAYS AFTER INSTALLATION |
||||
Cornea Grade |
1 |
2 |
3 |
4 |
7 |
(A)Opacity |
0 |
0 |
0 |
0 |
0 |
(B) Area Of Cornea Involved |
0 |
0 |
0 |
0 |
0 |
Score equals |
(0X0X0)=0 |
||||
|
|||||
Iris |
0 |
0 |
0 |
0 |
0 |
Score equals |
(0X5)=0 |
||||
|
|||||
Conjunctivae |
|
|
|
|
|
(A)Redness |
0 |
0 |
0 |
0 |
0 |
(B ) Chemosis |
0 |
0 |
0 |
0 |
0 |
(C) Discharge |
0 |
0 |
0 |
0 |
0 |
Score equals |
(0+0+0)X0=0 |
|
|
|
|
Applicant's summary and conclusion
- Interpretation of results:
- other: Not Irritating
- Conclusions:
- The test material alpha-Amyl cinnamaldehyde (CAS No: 122-40-7) did not produce any ocular lesions into the eye of each of three rabbits. Hence it was considered as not irritating.
- Executive summary:
An eye study of alpha-Amyl cinnamaldehyde (CAS No: 122-40-7) to determine if the test material produces any irritation when instilled into rabbits' eyes.
About 0.1ml ml of chemical was installed into the right of each albino rabbits while the other untreated eye served as control. The eyes were evaluated every twenty-four hours for tour days and then again on the seventh day.
The Installation of chemical did not produce any ocular lesions. Hence the chemical alpha-Amyl cinnamaldehyde (CAS No: 122-40-7) was considered as not irritating to the eyes of each rabbits.
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