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Administrative data

Description of key information

Acute oral toxicity, rats: LD50 = 8530 mg per kg body weight.
Acute dermal toxicity, rabbits: LD50 = 15.9 mL per kg body weight.
Acute toxicity, inhalation, rat: no mortality after exposure to test substance saturated vapour for 8 hours.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment
Qualifier:
no guideline followed
Deviations:
not specified
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
Control animals:
no
Sex:
not specified
Dose descriptor:
LD50
Effect level:
8 530 mg/kg bw
Based on:
test mat.
Mortality:
no data
Clinical signs:
no data
Gross pathology:
no data
Other findings:
no data

no data

Interpretation of results:
practically nontoxic
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
The LD50,oral,rat was 8.53 g per kg body weight when administered orally.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
8 530 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data
Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data
Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
ca. 8 h
Concentrations:
no data
No. of animals per sex per dose:
no data
Details on study design:
no data
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
other: air saturated with the vapour of the test substance, exposure for 8 hours
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: see above
Mortality:
no data
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data
Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
Saturated vapours of the test substance was survived for 8 hours by 100 % of the rats exposed.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating conc.
Value:
15.4 mg/m³

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment
Qualifier:
no guideline followed
Deviations:
not specified
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data
Species:
rabbit
Strain:
not specified
Sex:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Sex:
not specified
Dose descriptor:
LD50
Effect level:
15.9 mL/kg bw
Based on:
test mat.
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data
Interpretation of results:
practically nontoxic
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
The LD50,dermal,rabbit was 15.9 mL per kg body weight.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
15 600 mg/kg bw

Additional information

The LD50, oral, rat was 8530 mg per kg body weight.

he LD50,dermal,rabbit was 15.9 mL per kg body weight, with a rel. density of 0.9837 this yields 15600 mg/kg bw.

The LC0,inhalation,rat is the discriminating concentration reported above and it is based on the saturation concentration of the submitted substance in air, which is calculated from the vapour pressure of 0.164 Pa at 20 °C to 15.4 mg/m3.

Justification for classification or non-classification

No classification is derived from the results of acute oral, dermal and inhalation toxicity studies.