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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List IV
Author:
Smyth HF
Year:
1951
Bibliographic source:
Archives of Industrial Hygiene and Occupational Medicine vol 4, pp 119-122

Materials and methods

Test guideline
Qualifier:
no guideline followed
Deviations:
not specified
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibutyl fumarate
EC Number:
203-327-9
EC Name:
Dibutyl fumarate
Cas Number:
105-75-9
Molecular formula:
C12H20O4
IUPAC Name:
dibutyl but-2-enedioate
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
8 530 mg/kg bw
Based on:
test mat.
Mortality:
no data
Clinical signs:
no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
The LD50,oral,rat was 8.53 g per kg body weight when administered orally.