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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List IV
Author:
Smyth HF
Year:
1951
Bibliographic source:
Archives of Industrial Hygiene and Occupational Medicine vol 4, pp 119-122

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibutyl fumarate
EC Number:
203-327-9
EC Name:
Dibutyl fumarate
Cas Number:
105-75-9
Molecular formula:
C12H20O4
IUPAC Name:
dibutyl but-2-enedioate
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
ca. 8 h
Concentrations:
no data
No. of animals per sex per dose:
no data
Details on study design:
no data

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
other: air saturated with the vapour of the test substance, exposure for 8 hours
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: see above
Mortality:
no data
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
Saturated vapours of the test substance was survived for 8 hours by 100 % of the rats exposed.