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Short-term toxicity to fish

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Description of key information

No effects up to the limit of water solubility. 

Key value for chemical safety assessment

Additional information

One GLP Guideline study according to OECD 203 (limit test) is available investigating the short-term toxicity of didocosyl sebacate (CAS 42233-75-0) to freshwater fish (Parr, 2012). Due to the low aqueous solubility of the test item for the purposes of the test the test item was prepared using a slow stir method of preparation.

Following a preliminary range-finding test, seven fish were exposed to a single nominal loading rate of 100 mg/L for a period of 96 hours at a temperature of approximately 14°C under semi-static test conditions. The number of mortalities and any sub-lethal effects of exposure in each test and control vessel were determined 3 and 6 hours after the start of exposure and then daily throughout the test until termination after 96 hours.

The 96-Hour LL50 based on nominal loading rates was greater than 100 mg/L. The No Observed Effect Loading rate was >= 100 mg/L.

It was considered unnecessary and unrealistic to test at loading rates in excess of 100 mg/L. Total Organic Carbon (TOC) analysis of the test preparations at 0 hours (fresh media) and 24 and 96 hours (old media) showed measured test concentrations of less than the limit of quantitation (LOQ), which was considered to be 1.0 mg C/L.