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Short-term toxicity to aquatic invertebrates

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Description of key information

No effects up to the limit of water solubility. 

Key value for chemical safety assessment

Additional information

One GLP Guideline study conducted according to OECD 202 (limit test) is available investigating the short-term effects of didocosyl sebacate (CAS 42233-75-0) to freshwater invertebrates (Parr, 2012). Due to the low aqueous solubility of the test item for the purposes of the test the test item was prepared using a slow stir method of preparation. Following a preliminary range-finding test, twenty daphnids (4 replicates of 5 animals) were exposed to a slow stirred solution of the test item at single nominal loading rate of 100 mg/L for 48 hours at a temperature of 21°C under static test conditions. The number of immobilized Daphnia and any adverse reactions to exposure were recorded after 24 and 48 hours.

The 48-Hour EL50 for the test item to Daphnia magna based on nominal loading rates was greater than 100 mg/L. The No Observed Effect Loading rate was 100 mg/L. It was considered unnecessary and unrealistic to test at loading rates in excess of 100 mg/L. Samples of the control and 100 mg/L test preparation were taken at 0 (fresh media) and 48 hours (old media) for Total Organic Carbon (TOC) analysis. Given the background level of carbon in the control vessels and also the low level of carbon in the test vessels, it was considered that all the results were around the limit of quantitation of the analytical method