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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

No effects up to the limit of water solubility. 

Key value for chemical safety assessment

Additional information

One GLP Guideline study conducted according to OECD 201 is available investigating the toxicity of didocosyl sebacate (CAS 42233 -75-0) to freshwater algae (Vryenhoef, 2012). Due to the low aqueous solubility of the test item for the purposes of the test the test item was prepared using a slow stir method of preparation. Following a preliminary range-finding test, Pseudokirchneriella subcapitata was exposed to nominal loading rates of 1.0, 3.2, 10, 32 and 100 mg/L (three replicate flasks per concentration) for 72 hours, under constant illumination and shaking at a temperature of 24 ± 1 °C. Samples of the algal populations were removed daily and cell concentrations determined for each control and treatment group, using a Coulter® Multisizer Particle Counter.

Exposure of Pseudokirchneriella subcapitata to the test item gave EL50 values based on nominal loading rates of greater than 100 mg/L. The No Observed Effect Loading Rate based on nominal loading rates was >= 100 mg/L. Total Organic Carbon (TOC) analysis of the test preparations at 0 hours showed measured carbon concentrations to range from less than the limit of quantitation (LOQ), which was considered to be 1.0 mg C/L, to 7.7 mg C/L. A decline in measured carbon concentration was observed at 72 hours in the range of less than the control to 2.6 mg C/L.