Registration Dossier
Registration Dossier
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EC number: 202-634-5 | CAS number: 98-07-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Deficiencies: Purity of test substance is not given; small number of animals per group and method does not comply with the current standard (animals skin abraded)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Benzotrichloride was received from the study´s sponsor on August 31, 1978 (Velsicol Chemical Corporation) as lot: D8-195-1 appearing as transparent yellow liquid with white particles.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours under occlusive conditions
- Doses:
- 1000, 2000, 4000, 8000 mg/kg bw
- No. of animals per sex per dose:
- 2 male and 2 female rabbits per group
- Details on study design:
- The skin of one male and one female per group was abraded
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 000 mg/kg bw
- Remarks on result:
- other: 95% confidence interval 2681 - 5968 mg/kg bw for males and females combined
- Mortality:
- 4000 mg/kg bw: 1 male (day 3), 1 female (day 6)
8000 mg/kg bw: 2 males (day 2), 2 females (day 3) - Clinical signs:
- In males and females of the 4000 mg/kg bw treatment group hypoactivity and ataxia were the most pronounced pharmacotoxic signs. They persisted for the observation period of 14 d.
- Body weight:
- Starting with 2000 mg/kg bw a weight reduction was observed for female rabbits and also for males and females at 4000 mg/kg bw. This symptom was more pronounced in females.
- Gross pathology:
- irritation at application site, mottled or pale coloration of livers, brown or green fluid in stomach, brown intestinal contents, lung congestion (females only)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
