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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Authorized database

Data source

Reference
Reference Type:
other: Authorized database
Title:
Acute dermal toxicity study of CAS no:104-93-8
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus A Toxnet Database, 2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of Propionic acid in rats
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
propanoic acid
Cas Number:
79-09-4
Molecular formula:
C3H6O2
IUPAC Name:
propanoic acid
Details on test material:
- Name of test material (as cited in study report): Propionic acid
- Molecular formula (if other than submission substance): C3H6O2
- Molecular weight (if other than submission substance): 74.0784 g/mole
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report): Propionic acid
- Molecular formula (if other than submission substance): C3H6O2
- Molecular weight (if other than submission substance): 74.0784 g/mole
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
2600 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 600 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % Mortality observed
Mortality:
not specified
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be 2600 mg/kg bw when rats was treated with Propionic acid orally.
Executive summary:

In a acute oral toxicity study,rats was treated with Propionic acid in the concentration of 2600 mg/kg bw orally. 50 % mortality was observed in treated rats at 2600 mg/kg bw. Therefore, LD50 was considered to be2600mg/kg bw when rat were treated with Propionic acid orally.