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EC number: 225-190-4 | CAS number: 4706-78-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Authorized database
Data source
Reference
- Reference Type:
- other: Authorized database
- Title:
- Acute dermal toxicity study of CAS no:104-93-8
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus A Toxnet Database, 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of Propionic acid in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- propanoic acid
- Cas Number:
- 79-09-4
- Molecular formula:
- C3H6O2
- IUPAC Name:
- propanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Propionic acid
- Molecular formula (if other than submission substance): C3H6O2
- Molecular weight (if other than submission substance): 74.0784 g/mole
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Propionic acid
- Molecular formula (if other than submission substance): C3H6O2
- Molecular weight (if other than submission substance): 74.0784 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 2600 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % Mortality observed
- Mortality:
- not specified
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 2600 mg/kg bw when rats was treated with Propionic acid orally.
- Executive summary:
In a acute oral toxicity study,rats was treated with Propionic acid in the concentration of 2600 mg/kg bw orally. 50 % mortality was observed in treated rats at 2600 mg/kg bw. Therefore, LD50 was considered to be2600mg/kg bw when rat were treated with Propionic acid orally.
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