Registration Dossier
Registration Dossier
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EC number: 203-570-0 | CAS number: 108-30-5
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A total of 186 compounds were examined by short -term assays using rat bone marrow cells (chromosome aberrations in vivo) and silk worms.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Succinic anhydride
- EC Number:
- 203-570-0
- EC Name:
- Succinic anhydride
- Cas Number:
- 108-30-5
- Molecular formula:
- C4H4O3
- IUPAC Name:
- oxolane-2,5-dione
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Negative results on genotoxic effects were obtained from the in vivo chromosome aberration test in rat bone marrow cells.
- Executive summary:
A total of 186 compounds were examined by short -term assays using rat bone marrow cells (chromosome aberrations in vivo) and silk worms.
Result of the rat bone marrow cells (chromosome aberrations in vivo) was negative - no genotoxic effects
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