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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-02-06 to 2017-02-10
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2014
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
628 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 830 mg/L
Incubation duration:
72 h
Temp.:
20 °C
Remarks on result:
other: Mean of 6 measurements, 2 at each sampling time 24, 48 and 72h

1. Preliminary test (non-GLP):

The determination solubility in double distilled water was 366 mg/L. For the application dose for the definitive study, 1.8 g/L, as ca. the fivefold of the maximum solubility result, was used.

2. Water solubility results;

Water solubility has been measured at 20°C and pH: 6

Preincubation time Replicate No. Test substance concentration (mg/L)
24 h 1 647.1
2 631.1
48h 1 643.4
2 617.3
72h 1 617.4
2 610.6
Mean (24-72h) 627.8
Deviation (%) (24-72h) 6.0

Validity Criteria:

- Repeatability: The concentration measured in at least the samples with the two longest incubation times (48 and 72h) should not differ by more than 15%.

- Temperatures: Temperatures should be kept constant within +- 0.5°C

- Linearity: regression coefficient of calibration curve: 1.0000

- Specificity: no interference of the total area for target analyte was observed

- Accuracy: the mean recovery values of samples fortified with the analyte was determined to be 95%

- Precision: the relative standard deviation of repeated analysis of 5 independent fortification samples was 4.3%

- Repeatability of injection: one standard solution was injected 5 times. The relative standard deviation was 0.9%.

Conclusions:
The test item was found to have a water solubility of 627.8 mg/L at 20°C and a pH of 6.
Executive summary:

The water solubility of the test substance was determined according to OECD test guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6.

The solubility of the test substance was determined using the flask method at 20 +- 0.5 °C with pre-incubation at 30 +- 0.5°C. Measurements were performed after 24, 48 and 72h.

The water solubility of the test substance was determined to be 627.8 mg/L (20°C, pH 6).

Description of key information

For this endpoint the water solubility has been determined experimentally according to OECD 105, flask method and GLP. The test item was found to have a water solubility of 627.8 mg/L at 20°C and a pH of 6.

Key value for chemical safety assessment

Water solubility:
627.8 mg/L
at the temperature of:
20 °C

Additional information