Registration Dossier
Registration Dossier
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EC number: 200-237-1 | CAS number: 55-55-0
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/sediments:
Using BCFBAF Program (v3.00) model of EPI suite 2017 the estimated bio concentration factor (BCF) for Bis(4-hydroxy-N-methylanilinium) sulphate (CAS No. 55-55-0) is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical Bis(4-hydroxy-N-methylanilinium) sulphate is non bioaccumulative in food chain.
Additional information
Bioaccumulation: aquatic/sediments:
Predicted data study for the target compound (4-hydroxy-N-methylanilinium) sulphate (CAS No. 55-55-0) and two supporting weight of evidence studies for its read across chemical were reviewed for the bioaccumulation end point which are summarized as below:
In a prediction done by using BCFBAF Program (v3.00) model of EPI suite 2017 the bio concentration factor (BCF) for Bis(4-hydroxy-N-methylanilinium) sulphate (CAS No. 55-55-0) estimated was 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000.
Next supporting weight of evidence study done from Hazardous Substance Data Bank (HSDB, 2017) of read across chemical 4-(methylamino)phenol (CAS no. 150-75-4) and BCF value determined was 3.2 dimensionless by using log Kow of 0.79 and regression derived equation.
Another supporting weight of evidence study done from authoritative database (J check, 2017) in this study Bioaccumulation test was conducted for 6 weeks for determination the bioconcentration factor (BCF) of read across chemical 4-(anilino)phenol (CAS no 122-37-2) on test organism Cyprinus carpio. Nominal concentrations used were 1st Concentration area: 0.1 mg/L (w/v), 2nd Concentration area: 0.01 mg/L (w/v) and Range finding study was carried out on Rice fish (Oryzias latipes) LC50 (48h) 0.714 mg/L. The vehical used in this study was HCO-40, olive oil. The lipid content of fish at start of exposure was 4.2%. Thus according to flow through Fish Test the BCF value for read across chemical 4-(anilino)phenol was observed to be to be in range 3.3-9.2 dimensionless at dose concentration 0.1 mg/L and 14-49 dimensionless at dose concentration 0.01 mg/L on test organism Cyprinus carpio during 6 weeks period.
On the basis of above results for target chemical Bis(4-hydroxy-N-methylanilinium) sulphate (CAS No. 55-55-0) (from EPI suite 2017) and for its read across chemicals (From HSDB and J check) it can be concluded that the BCF value of test substance Bis(4-hydroxy-N-methylanilinium) sulphate is 16.26 L/Kg which does not exceed the bioconcentration threshold of 2000, indicating that the chemical Bis(4-hydroxy-N-methylanilinium)sulphate is expected to be non bioaccumulative in the food chain.
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