Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-237-1 | CAS number: 55-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary literature.
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Daphnia magna Bioassay was carried out under static condition to study the effects of Bis(4-hydroxy-N-methylanilinium) sulphate on aquatic environment.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: p-Methylaminophenol sulfate- IUPAC name: Bis(4-hydroxy-N-methylanilinium) sulphate- Molecular formula: C14H20N2O6S- Molecular weight: 344.386 g/mole- Smiles:CNc1ccc(cc1)O.CNc1ccc(cc1)O.OS(=O)(=O)O- Inchl: 1S/2C7H9NO.H2O4S/c2*1-8-6-2-4-7(9)5-3-6;1-5(2,3)4/h2*2-5,8-9H,1H3;(H2,1,2,3,4)- Substance type: Organic- Physical state: Solid crystalline (off white - white)
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Details on test solutions:
- - Stock solution: At the start of each bioassay, appropriate dilutions of each test chemical were prepared and dispensed into 150-milliliter Griffin beakers. The pH of each test solution was adjusted to between pH 7.07.5.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM- Common name: water flea- Source: Carolina Biological Supply company, Burlington North carolina.- Method of breeding: A more satisfactory culture medium was obtained by blending approximately 2 grams of alfalfa pellets with 3-4 dried brine shrimp per liter of water. This medium was replaced every 2-3 days and was successful in promoting reproduction of the stock culture.- Food type: algae
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 54.5 (37.0-75.0) F
- pH:
- 7.0-7.5
- Details on test conditions:
- - Test vessel: one-gallon, wide-mouth, - Material, size, headspace, fill volume: glass jars
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.019 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: : toxic
- Conclusions:
- The lethal concentration LC50 to 50% of daphnia magna is 0.019 mg/L at 96 hrs. Mortality was measured during the test. It can be concluded from the value that the Bis(4-hydroxy-N-methylanilinium) sulphate is toxic to the aquatic environment.
- Executive summary:
Daphnia magna Bioassay was carried out under static condition to study the effects of Bis(4-hydroxy-N-methylanilinium) sulphate on aquatic environment. At the start of each bioassay, appropriate dilutions of each test chemical were prepared and dispensed into 150 milliliter Griffin beakers. The pH of each test solution was adjusted to between pH 7.0-7.5. A final volume of 100-110 milliliters was used throughout the testing program. Controls, which contained only Daphnia in dilution water, were included in every bioassay. Adult mortalities were recorded on a daily basis. Births and newborn mortalities observed during the experiment were noted but not enumerated. The lethal concentration LC50 to 50% of daphnia magna is 0.019 mg/L at 96 hrs. It can be concluded from the value that the Bis(4-hydroxy-N-methylanilinium) sulphate is toxic to the aquatic environment and can be considered as “aquatic Chronic 1” as per classification for the aquatic environment.
Reference
Bioassay data summary of Daphnia Magna
|
|
| Cumulative mortalities | Percent mortality at |
| |||
Test chemical | Conc.(mg/l) | Starting population | 24 hr | 48 hr | 72 hr | 96 hr | 96 hrs | 96hr LC50 or range (mg/l) |
4-methyl Amino Phenol Sulfate (VIIID8) | 0.3 | 11 | 2 | 4 | 9 | 9 | 81.8 | 0.019 |
0.09 | 11 | 1 | 3 | 7 | 8 | 72.7 | ||
0.03 | 10 | 2 | 3 | 4 | 7 | 70.0 | ||
0.009 | 10 | 1 | 1 | 2 | 4 | 40.0 | ||
0.0 | 53 | 1 | 2 | 2 | 4 | 7.5 |
Description of key information
Daphnia magna Bioassay was carried out under static condition to study the effects of Bis(4-hydroxy-N-methylanilinium) sulphate on aquatic environment. At the start of each bioassay, appropriate dilutions of each test chemical were prepared and dispensed into 150 milliliter Griffin beakers. The pH of each test solution was adjusted to between pH 7.0-7.5. A final volume of 100-110 milliliters was used throughout the testing program. Controls, which contained only Daphnia in dilution water, were included in every bioassay. Adult mortalities were recorded on a daily basis. Births and newborn mortalities observed during the experiment were noted but not enumerated. The lethal concentration LC50 to 50% of daphnia magna is 0.019 mg/L at 96 hrs. It can be concluded from the value that the Bis(4-hydroxy-N-methylanilinium) sulphate is toxic to the aquatic environment and can be considered as “aquatic Chronic 1” as per classification for the aquatic environment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.019 mg/L
Additional information
Daphnia magna Bioassay was carried out under static condition to study the effects of Bis(4-hydroxy-N-methylanilinium) sulphate on aquatic environment. At the start of each bioassay, appropriate dilutions of each test chemical were prepared and dispensed into 150 milliliter Griffin beakers. The pH of each test solution was adjusted to between pH 7.0-7.5. A final volume of 100-110 milliliters was used throughout the testing program. Controls, which contained only Daphnia in dilution water, were included in every bioassay. Adult mortalities were recorded on a daily basis. Births and newborn mortalities observed during the experiment were noted but not enumerated. The lethal concentration LC50 to 50% of daphnia magna is 0.019 mg/L at 96 hrs. It can be concluded from the value that the Bis(4-hydroxy-N-methylanilinium) sulphate is toxic to the aquatic environment and can be considered as “aquatic Chronic 1” as per classification for the aquatic environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.