Bis(4-hydroxy-N-methylanilinium) sulphate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data from secondary source

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Acute oral toxicity for CAS No.: 55-55-0

Author:

U.S. National Library of Medicine

Year:

2017

Bibliographic source:

ChemIDplusA TOXNET Database, 2017

Reference 2

Reference Type:

secondary source

Title:

Initial Submission: Letter from Eastman Kodak Co to USEPA Regarding Toxicity Studies of 4-(methylamino)phenol Sulfate with Attachments and Cover Letter dated 082892.

Author:

NTRL

Year:

1992

Bibliographic source:

OTS0570966, NTRL, dated 082892

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute oral toxicity study of 4-Methylaminophenol sulphate was performed in mouse.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Bis(4-hydroxy-N-methylanilinium) sulphate

EC Number:

200-237-1

EC Name:

Bis(4-hydroxy-N-methylanilinium) sulphate

Cas Number:

55-55-0

Molecular formula:

C14H20N2O6S

IUPAC Name:

bis(4-hydroxy-N-methylanilinium) sulfate

Test material form:

solid: crystalline

Details on test material:

- Name of test material: p-Methylaminophenol sulfate
- IUPAC name: Bis(4-hydroxy-N-methylanilinium) sulphate
- Molecular formula: C14H20N2O6S
- Molecular weight: 344.386 g/mole
- Smiles:CNc1ccc(cc1)O.CNc1ccc(cc1)O.OS(=O)(=O)O
- Inchl: 1S/2C7H9NO.H2O4S/c2*1-8-6-2-4-7(9)5-3-6;1-5(2,3)4/h2*2-5,8-9H,1H3;(H2,1,2,3,4)
- Substance type: Organic
- Physical state: Solid crystalline (off white - white)

Specific details on test material used for the study:

- Name of test material: p-Methylaminophenol sulfate- IUPAC name: Bis(4-hydroxy-N-methylanilinium) sulphate- Molecular formula: C14H20N2O6S- Molecular weight: 344.386 g/mole- Smiles:CNc1ccc(cc1)O.CNc1ccc(cc1)O.OS(=O)(=O)O- Inchl: 1S/2C7H9NO.H2O4S/c2*1-8-6-2-4-7(9)5-3-6;1-5(2,3)4/h2*2-5,8-9H,1H3;(H2,1,2,3,4)- Substance type: Organic- Physical state: Solid crystalline (off white - white)

Test animals

Species:

mouse

Strain:

not specified

Sex:

male

Details on test animals or test system and environmental conditions:

No data available

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

other: 0.5% Jaguar(guar-gum)

Details on oral exposure:

Details on exposureVEHICLE- Concentration in vehicle:565 mg/kg bw- Amount of vehicle (if gavage): No data available- Justification for choice of vehicle: Test material soluble in vehicle - Lot/batch no. (if required): No data available- Purity: No data availableMAXIMUM DOSE VOLUME APPLIED: No data availableDOSAGE PREPARATION (if unusual): 10% suspension of the compound in 0.5% Jaguar(guar-gum)CLASS METHOD (if applicable)- Rationale for the selection of the starting dose No data available

Doses:

565mg/kg bw

No. of animals per sex per dose:

No data available

Control animals:

not specified

Details on study design:

No data available

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

565 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality was observed

Mortality:

50% mortality was observed

Clinical signs:

other: Behavioral changes like somnolence (general depressed activity) and tremor were observed

Gross pathology:

No data available

Other findings:

Effect on kidney, ureter, and bladder and changes in urine composition were noted.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

LD50 was considered to be 565mg/kg bw. When mouse were treated with 4-Methylaminophenol sulphate (55-55-0) orally.

Executive summary:

In acute oral toxicity study, mice were treated with4-Methylaminophenol sulphate (55-55-0)orally. The dose concentration was prepared in10% suspension of the compound in 0.5% Jaguar (guar-gum).50% mortality was observed in treated mouse at 565 mg/kg bw. Behavioral changes like somnolence (general depressed activity) and tremor were observed also effect on kidney, ureter, and bladder and changes in urine composition were noted in treated mice. Therefore, LD50 was considered to be 565mg/kg bw. When mouse were treated with4-Methylaminophenol sulphate(55-55-0) orally.