Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 228-544-6 | CAS number: 6291-84-5
Endpoint summary
Administrative data
Link to relevant study record(s)
- Justification for data waiving:
- other:
Reference
Description of key information
The water solubility of the chemical is reported to be 1000000 mg/L indicating high water solubility which will ensure that the chemical shall be transferred by the blood to various parts of the body. The Log Kow value of the chemical is 0.66 which according to the Lipinski rule shall ensure that the chemical shall be bio-available if ingested inside the human or animal body. The chemical has a Harmonized Classification in the acute toxicity by the oral, inhalation and the dermal route of exposure.
The chemical (3-aminopropyl)(methyl)amine is used as an intermediate for the manufacture of other chemicals. Thus, exposure by the oral route is unlikely but exposure by the dermal route is likely. There are reports that suggest that toxicity by the inhalation route is also likely. The bio-concentration factor (BCF) of the chemical (3-aminopropyl)(methyl)amine is reported to be 3.162 L/kg wet-wt (Predicted value) which suggest a low bio-accumulation potential (Bio-accumulation factor, BAF = 0.913 L/kg wet-wt).
However, in the absence of any authoritative information pertaining to the absorption, distribution, metabolism and excretion of the chemical (3-aminopropyl)(methyl)amine, bio-accumulation potential cannot be judged relying on certain physico-chemical properties and available information on BCF and BAF.
Key value for chemical safety assessment
Additional information
The water solubility of the chemical is reported to be 1000000 mg/L indicating high water solubility which will ensure that the chemical shall be transferred by the blood to various parts of the body. The Log Kow value of the chemical is 0.66 which according to the Lipinski rule shall ensure that the chemical shall be bio-available if ingested inside the human or animal body. The chemical has a Harmonized Classification in the acute toxicity by the oral, inhalation and the dermal route of exposure.
The chemical (3-aminopropyl)(methyl)amine is used as an intermediate for the manufacture of other chemicals. Thus, exposure by the oral route is unlikely but exposure by the dermal route is likely. There are reports that suggest that toxicity by the inhalation route is also likely. The bio-concentration factor (BCF) of the chemical (3-aminopropyl)(methyl)amine is reported to be 3.162 L/kg wet-wt (Predicted value) which suggest a low bio-accumulation potential (Bio-accumulation factor, BAF = 0.913 L/kg wet-wt).
However, in the absence of any authoritative information pertaining to the absorption, distribution, metabolism and excretion of the chemical (3-aminopropyl)(methyl)amine, bio-accumulation potential cannot be judged relying on certain physico-chemical properties and available information on BCF and BAF.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
