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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from NTRL

Data source

Reference
Reference Type:
secondary source
Title:
Initial submission: Letter from Eastman Kodak Co to USEPA Regarding Basictoxicity of 3-methylaminopropylamine with Attachments and Cover Letter dated 9/4/92.
Author:
NTRL
Year:
1992
Bibliographic source:
OTS0555335, NTRL, dated 9/4/92

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
To determine acute oral toxicity in rat by using 3-aminopropylmethylamine
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-aminopropylmethylamine
EC Number:
228-544-6
EC Name:
3-aminopropylmethylamine
Cas Number:
6291-84-5
Molecular formula:
C4H12N2
IUPAC Name:
(3-aminopropyl)(methyl)amine
Details on test material:
SMILES:CNCCCN
Specific details on test material used for the study:
- Name of test material: (3-aminopropyl)(methyl)amine
- Molecular formula: C4H12N2
- Molecular weight: 88.1528 g/mol
- Smiles notation: N(CCCN)C
- InChl: 1S/C4H12N2/c1-6-4-2-3-5/h6H,2-5H2,1H3
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
951 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days (or other?): not specified
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: not specified
- Other examinations performed: Mortality and clinical signs were examined.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
951
Based on:
test mat.
95% CL:
677 - 1 336
Remarks on result:
other: 50 % mortality observed
Mortality:
50% mortality was observed in treated rats at 951 mg/kg bw
Clinical signs:
other: Hematuria and blood in urine was observed in treated rats, probably resulting from the ulcerative effect of the compound.
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 was considered to be 951 mg/kg bw with confidential limit of 677-1336 mg/kg, when rat was treated with 3-aminopropylmethylamine orally.
Executive summary:

In a acute oral toxicity study, rat were treated with (3-aminopropyl)(methyl)amine orally. 50% mortality was observed in treated rats at 951 mg/kg bw. Hematuria and blood in urine was observed in treated rats, probably resulting from the ulcerative effect of the compound. Therefore, LD50 was considered to be 951 mg/kg bw with confidential limit of 677-1336 mg/kg, when rat was treated with 3-aminopropylmethylamine orally.