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Registration Dossier
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EC number: 228-544-6 | CAS number: 6291-84-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from NTRL
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Initial submission: Letter from Eastman Kodak Co to USEPA Regarding Basictoxicity of 3-methylaminopropylamine with Attachments and Cover Letter dated 9/4/92.
- Author:
- NTRL
- Year:
- 1 992
- Bibliographic source:
- OTS0555335, NTRL, dated 9/4/92
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- To determine acute oral toxicity in rat by using 3-aminopropylmethylamine
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3-aminopropylmethylamine
- EC Number:
- 228-544-6
- EC Name:
- 3-aminopropylmethylamine
- Cas Number:
- 6291-84-5
- Molecular formula:
- C4H12N2
- IUPAC Name:
- (3-aminopropyl)(methyl)amine
- Details on test material:
- SMILES:CNCCCN
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: (3-aminopropyl)(methyl)amine
- Molecular formula: C4H12N2
- Molecular weight: 88.1528 g/mol
- Smiles notation: N(CCCN)C
- InChl: 1S/C4H12N2/c1-6-4-2-3-5/h6H,2-5H2,1H3
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 951 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?): not specified
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: not specified
- Other examinations performed: Mortality and clinical signs were examined. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 951
- Based on:
- test mat.
- 95% CL:
- 677 - 1 336
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50% mortality was observed in treated rats at 951 mg/kg bw
- Clinical signs:
- other: Hematuria and blood in urine was observed in treated rats, probably resulting from the ulcerative effect of the compound.
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 was considered to be 951 mg/kg bw with confidential limit of 677-1336 mg/kg, when rat was treated with 3-aminopropylmethylamine orally.
- Executive summary:
In a acute oral toxicity study, rat were treated with (3-aminopropyl)(methyl)amine orally. 50% mortality was observed in treated rats at 951 mg/kg bw. Hematuria and blood in urine was observed in treated rats, probably resulting from the ulcerative effect of the compound. Therefore, LD50 was considered to be 951 mg/kg bw with confidential limit of 677-1336 mg/kg, when rat was treated with 3-aminopropylmethylamine orally.
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