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EC number: 228-544-6 | CAS number: 6291-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from NTRL.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Initial submission: Letter from Eastman Kodak Co to USEPA Regarding Basictoxicity of 3-methylaminopropylamine with Attachments and Cover Letter dated 9/4/92.
- Author:
- NTRL
- Year:
- 1 992
- Bibliographic source:
- OTS0555335, NTRL, dated 9/4/92
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mention beow
- Principles of method if other than guideline:
- To evaluate the toxic potential of 3-methylaminopropylamine in rats by inhalation for 13 days, 6 hour /day.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3-aminopropylmethylamine
- EC Number:
- 228-544-6
- EC Name:
- 3-aminopropylmethylamine
- Cas Number:
- 6291-84-5
- Molecular formula:
- C4H12N2
- IUPAC Name:
- (3-aminopropyl)(methyl)amine
- Test material form:
- liquid
- Details on test material:
- - Name of test material : (3-aminopropyl)(methyl)amine; 3-Amino-1-methylaminopropane
- Molecular formula : C4H12N2
- Molecular weight : 88.1528 g/mol
- Smiles notation : N(CCCN)C
- InChl : 1S/C4H12N2/c1-6-4-2-3-5/h6H,2-5H2,1H3
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material : (3-aminopropyl)(methyl)amine; 3-Amino-1-methylaminopropane
- Molecular formula : C4H12N2
- Molecular weight : 88.1528 g/mol
- Smiles notation : N(CCCN)C
- InChl : 1S/C4H12N2/c1-6-4-2-3-5/h6H,2-5H2,1H3
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- 7.2 µm
- Geometric standard deviation (GSD):
- 1.41
- Details on inhalation exposure:
- Details on inhalation exposure
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Animals were exposed in stainless steel and glass inhalation chambers having an effective animal exposure volume of 420 liters. Atmospheres were produced by passing air over the surface of the liquid contained in a three necked flask maintained at 35° C tor 61 mg/m and 50° C for 189.3, mg/m3 . Vapor laden air exiting the flask vas diluted at a T at which point a chemical or physical reaction occurred resulting in the production of an aerosol. Particle size analysis was done by using a Royco Analyzer over the course or exposure resulted
in a stable distribution with an aerodynamic mass median diameter of 7.2µm and geometric standard deviation of 1.41.
TEST ATMOSPHERE
- Brief description of analytical method used: Approximately82% of the particles was less than 10 um in diameter. Chamber concentrations were determined every 0.5 hour by gas chromatography of sample collected in midget impingers.
- Samples taken from breathing zone: yes - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- using gas chromatography
- Duration of treatment / exposure:
- 13 days
- Frequency of treatment:
- Single exposure for 6 hour/day
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/m³ air
- Dose / conc.:
- 61 mg/m³ air
- Dose / conc.:
- 189.3 mg/m³ air
- No. of animals per sex per dose:
- Total 12 animals
0.0 mg/m3- four rats
61.0 mg/m3 - four rats
189.3mg/m3- four rats - Control animals:
- yes, concurrent vehicle
- Details on study design:
- Details on study design
Dose were selected from preliminary study
Examinations
- Observations and examinations performed and frequency:
- Observations and examinations performed & frequency
CAGE SIDE OBSERVATIONS: Not specified
DETAILED CLINICAL OBSERVATIONS: Yes
BODY WEIGHT:
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Not specified
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: Not specified
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: Not specified
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): Not specified
OPHTHALMOSCOPIC EXAMINATION: Not specified
HAEMATOLOGY: Not specified
CLINICAL CHEMISTRY: Not specified
URINALYSIS: Not specified
NEUROBEHAVIOURAL EXAMINATION: Not specified
OTHER: - Sacrifice and pathology:
- Sacrifice and pathology
GROSS PATHOLOGY: Yes, macroscopic examination for nasal passages, trachea and lung were observed.
HISTOPATHOLOGY: Yes, microscopic examination for nasal passages, trachea and lung were observed. - Statistics:
- Not specified.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Description (incidence and severity):
- No significant change were observed at dose level of 61.0 and 189.3mg/m3 in treated group compare to control.
- Mortality:
- not specified
- Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- No significant change were observed at dose level of 61.0 and 189.3mg/m3 in treated group compare to control.
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- no effects observed
- Description (incidence and severity):
- No significant change were observed at dose level of 61.0 and 189.3mg/m3 in treated group compare to control.
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- effects observed, non-treatment-related
- Description (incidence and severity):
- As though nasal irrttion was observ ed but no significant change were observed at dose level of 61.0 and 189.3mg/m3 in treated group compare to control.
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- The substance is a severe irritant.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 189.3 mg/m³ air
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- clinical signs
- gross pathology
- histopathology: non-neoplastic
- Remarks on result:
- other: No significant change were observed at dose level of 61.0 and 189.3mg/m3 in treated group compare to control.
Target system / organ toxicity
- Critical effects observed:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
Applicant's summary and conclusion
- Conclusions:
- NOAEL was considered to be 189.3mg/m3 for 3-methylaminopropylamine in rats by inhalation for subacute study.
- Executive summary:
In a Repeated inhalation study for 3-methylaminopropylamine in rats by inhalation was observed. The animals were exposed to test material at the concentration of 0.0 , 61.0 and 189.3mg/m3for 13 days by single exposure for 6 hour/day. As no statically significant effects were observed on the clinical sign, gross pathology and histopathology of the treated animal’s other then nasal irritation. This nasal irritation is due to irritant nature of the substance .Therefore NOAEL was considered to be 189.3mg/m3 for3-methylaminopropylamine in rats by inhalation.
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