Registration Dossier
Registration Dossier
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EC number: 229-445-0 | CAS number: 6535-70-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Authoritative database
Data source
Reference
- Reference Type:
- other: Authoritative database
- Title:
- Acute oral toxicity of CAS No.: 117-62-4
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplusA TOXNET Database, 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of 2-aminonaphthalene-1,5-disulfonic acid in rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-aminonaphthalene-1,5-disulphonic acid
- EC Number:
- 204-201-6
- EC Name:
- 2-aminonaphthalene-1,5-disulphonic acid
- Cas Number:
- 117-62-4
- Molecular formula:
- C10H9NO6S2
- IUPAC Name:
- 2-aminonaphthalene-1,5-disulfonic acid
- Details on test material:
- SMILES:Nc1ccc2c(S(O)(=O)=O)cccc2c1S(O)(=O)=O
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-aminonaphthalene-1,5-disulfonic acid
- Molecular formula (if other than submission substance): C10H9NO6S2
- Molecular weight (if other than submission substance): 303.314 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 5430 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 430 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- 50% mortality was observed in treated rat at 5430 mg/kg bw.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 5430 mg/kg bw. When rat were treated with 2-aminonaphthalene-1,5-disulfonic acid orally.
- Executive summary:
In a acute oral toxicity study, rat were treated with 2-aminonaphthalene-1,5-disulfonic acid orally. 50% mortality was observedin treated rat at 5430 mg/kg bw. Therefore, LD50 was considered to be 5430 mg/kg bw when rat were treated with2-aminonaphthalene-1,5-disulfonic acid orally.
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