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EC number: 203-870-1 | CAS number: 111-44-4
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- No details provided
- Analytical monitoring:
- yes
- Details on sampling:
- Frequency of analysis: 0th, 2nd, 6th, 8th, 14th, 16th day
- Vehicle:
- not specified
- Details on test solutions:
- No data
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- No data
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Hardness:
- No data
- Test temperature:
- 20 +/- 1°C
- pH:
- No data
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Conductivity:
- No data
- Nominal and measured concentrations:
- Nominal concentrations: 100, 31.3, 9.77, 3.05, 0.954 mg/L (geometric ratio: 3.2), control
- Details on test conditions:
- TEST SYSTEM
- Fill volume: 800 mL per vessel
- Aeration: Not specified
- Renewal rate of test solution: once every other day
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 4
TEST MEDIUM / WATER PARAMETERS: no data
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light / 8 hours dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8 - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 18.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other:
- Remarks:
- 95% CL: 16.0 - 21.6 mg/L
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 9.77 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.05 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- parental
- Details on results:
- No further details provided
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 21-d NOEC (based on reproduction) was determined to be 3.05 mg/L.
- Executive summary:
This study was conducted on behalf of the Japanese Ministry of Environment (MOE). The methodology was based on OECD Technical Guideline N°211 under GLP. 4 replicate vessels containing 10 test animals each were used to evaluate the long-term toxicity of Bis(2-chloroethyl) ether to Daphnia magna. Based on reproduction, the NOEC was determined to be 3.05 mg/L. The LOEC was 9.77 mg/L. As no detailed information was available, a reliability factor of 2 was assigned to this guideline study.
Reference
Description of key information
The study was conducted on behalf of the Japanese Ministry of Environment (MOE). The methodology was based on OECD Technical Guideline N°211 under GLP. 4 replicate vessels containing 10 test animals each were used to evaluate the long-term toxicity of Bis(2-chloroethyl) ether to Daphnia magna. Based on reproduction, the NOEC was determined to be 3.05 mg/L. The LOEC was 9.77 mg/L. As no detailed information was available, a reliability factor of 2 was assigned to this guideline study.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.05 mg/L
Additional information
A single study reports long-term toxicity data on aquatic invertebrates. This study was conducted on behalf of the Japanese Ministry of Environment (MOE). The methodology was based on OECD Technical Guideline N°211 under GLP. 4 replicate vessels containing 10 test animals each were used to evaluate the long-term toxicity of Bis(2-chloroethyl) ether to Daphnia magna. Based on reproduction, the NOEC was determined to be 3.05 mg/L. The LOEC was 9.77 mg/L.As no detailed information was available, a reliability factor of 2 was assigned to this guideline study.
Conclusion: Based on the available information, the GHS-UN classification criteria are not met.
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