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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
It is not clear if the administered dose refers to the 10 % solution prepared or to BCEE. This causes uncertainty in the interpretation of the results

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1981

Materials and methods

Principles of method if other than guideline:
No information provided
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-chloroethyl) ether
EC Number:
203-870-1
EC Name:
Bis(2-chloroethyl) ether
Cas Number:
111-44-4
Molecular formula:
C4H8Cl2O
IUPAC Name:
1-chloro-2-(2-chloroethoxy)ethane
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
propylene glycol
Duration of exposure:
24 h

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
90 mg/kg bw
95% CL:
>= 55 - <= 145
Remarks on result:
other: It is not stated if the reported LD50 of 90 mg/kg bw is based on the applied substance or the BCEE content.
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
9 mg/kg bw
95% CL:
>= 5.5 - <= 14.5
Remarks on result:
other: It is not stated if the reported LD50 of 90 mg/kg bw is based on the applied substance or the ai content. As worst case scenario, it is assumed that the LD50 is based on the total applied material. Hence, the LD50 based on ai is 10% of the applied amount

Applicant's summary and conclusion

Interpretation of results:
Category 1 based on GHS criteria
Conclusions:
Following exposure by skin contact to a 10 % Bis(2-chloroethyl) ether solution in propylene glycol for 24 hours, the rabbit LD50 was found to be 90 mg/kg bw. Assuming that the LD50 is based on the total applied material, the LD50 based on Bis(2-chloroethyl) ether is 10% of the applied amount, i.e., 9 mg/kg bw. This data classifies the substance in the Acute Catgeory I according to GHS criteria.
Executive summary:

This handbook reports the results of an internal toxicity test from Dow Chemical Co. Following exposure by skin contact to a 10 % Bis(2-chloroethyl) ether solution in propylene glycol for 24 hours, the rabbit LD50 was found to be 90 mg/kg bw. It is not stated if the reported LD50 of 90 mg/kg bw is based on the applied substance or the Bis(2-chloroethyl) ether content. As worst case scenario, it is assumed that the LD50 is based on the total applied material. Hence, the LD50 based on Bis(2-chloroethyl) ether is 10% of the applied amount, i.e., 9 mg/kg bw. This data classifies the substance in the Acute Category I according to GHS criteria.