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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Dissociating properties:
yes
No.:
#1
pKa:
5.17
Temp.:
21.5 °C
Remarks on result:
other: Titration with NaOH
No.:
#2
pKa:
5.02
Temp.:
21.5 °C
Remarks on result:
other: Titration with NaOH
No.:
#3
pKa:
5.19
Temp.:
21.5 °C
Remarks on result:
other: Titration with NaOH
No.:
#4
pKa:
5.12
Temp.:
21.5 °C
Remarks on result:
other: Titration with NaOH

When the test substance was titrated 0.0967 N NaOH, one endpoint was detected.  When the same amount for the titrations performed using 0.0958 N HCl, no endpoint was detected.

Conclusions:
The estimated pKa value for the test substance was determined to be 5.1 log units.

Description of key information

pKa: 5.1 at 21.5C (OECD TG 112)

Key value for chemical safety assessment

pKa at 20°C:
5.1

Additional information