Registration Dossier
Registration Dossier
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EC number: 411-490-4 | CAS number: 7027-11-4 ISOPHORONENITRILE, IPN
Endpoint summary
Administrative data
Description of key information
Two studies regarding skin irritation of the test item Isophorone nitrile were conducted in rabbits. According to the outcome of both studies it has to be concluded that the test item Isophorone nitrile is not irritant to the skin. Two studies regarding eye irritation of the test item Isophorone nitrile were conducted in rabbits (Asta, 1990; Hüls AG, 1985).According to the outcome of both studies it has to be concluded that the test item Isophorone nitrile is not irritant to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Studies in animals:
Skin irritation
Two studies regarding skin irritation of the test item Isophorone nitrile were conducted in rabbits (Asta, 1990; Hüls AG, 1985). Altrough both studies have the same reliability and leading to the same conclusions, the newer study (Asta, 1990) was choosen to be the key study because this study was performed under GLP conditions. According to the outcome of both studies it has to be concluded that the test item Isophorone nitrile is not irritant to the skin.
Eye irritation
Two studies regarding eye irritation of the test item Isophorone nitrile were conducted in rabbits (Asta, 1990; Hüls AG, 1985). Altrough both studies have the same reliability and leading to the same conclusions, the newer study (Asta, 1990) was choosen to be the key study because this study was performed under GLP conditions. According to the outcome of both studies it has to be concluded that the test item Isophorone nitrile is not irritant to eyes.
Justification for classification or non-classification
Regarding irritant properties to skin and eyes the substance 3-cyano-3,5,5-trimethylcyclohexanone (Isophorone nitrile) is not classified according to the criteria of EC Directive 67/548/EEC.
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