Registration Dossier
Registration Dossier
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EC number: 211-185-4 | CAS number: 632-79-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is well reported but does not include information re GLP status.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 72-1 (Fish Acute Toxicity Test)
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- acetone was used as vehicle
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- Total hardness as CaCO3: 46 mg/L
- Test temperature:
- 12 degress C +/- 0.5 degrees C
- pH:
- Ranged from 6.77 - 7.28 throughout the test.
- Dissolved oxygen:
- Ranged from 7.4 - 9.1 throughout the test.
- Nominal and measured concentrations:
- 0, Solvent Control, 1, 1.8, 3.2, 5.6 or 10 mg/L
- Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: No fish died during the test
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96 hr LC50 in rainbow trout was > 10mg/L.
- Executive summary:
The 96 hr LC50 in rainbow trout was > 10mg/L, the highest dose tested.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is well reported with no information regarding GLPs.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- yes
- Test organisms (species):
- Lepomis macrochirus
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 d
- Post exposure observation period:
- No
- Hardness:
- 46 mg/L
- Test temperature:
- 22 +/- 0.5 degrees C
- pH:
- Ranged from 6.39 - 7.39
- Dissolved oxygen:
- Ranged from 1.7 - 8.7 mg/L
- Nominal and measured concentrations:
- 0, Solvent Control, 1.0, 1.8, 3.2, 5.6 , 10.0 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: No fish died during the test.
- Sublethal observations / clinical signs:
The 96 hr LC50 was > 10 mg/L, the highest dose tested.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96 hr LC50 was > 10 mg/L, the highest dose tested.
- Executive summary:
The 96 hr LC50 in the bluegill sunfish was > 10 mg/L, the highest dose tested.
Referenceopen allclose all
Description of key information
Two 96 hr tests in fish, and estimated values.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 10 mg/L
Marine water fish
Marine water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 20.471 mg/L
Additional information
Two short-term studies are currently available on trout and bluegill sunfish. Range concentration tested were between 0 -10 mg/L. LC50 (96h) for both tests were > 10 mg/L, the highest dose tested.
The ECOSAR-estimated 96 -hr LC50 in freshwater fish for the hydrolysis product TBPA-acid* is 17.983 mg/L, which is higher than the ECOSAR-estimated water solubility (0.104 mg/L) of the hydrolysis product. The ECOSAR-estimated LC50 of TBPA-acid in saltwater fish is 20.471 mg/L, which is higher than the estimated water solubiity. Based on this, neither TBPA nor TBPA-acid are expected to be toxic to fish.
*ECOSAR class for TBPA-acid is Neutral Organics-acid (ECOSAR V1.00)
Interestingly, when running ECOSAR for TBPA-anhydride* with the measured water solubility (see section 4.8), the LC50 (96 hrs) to fish is 372.167 mg/L in freshwater meaning that the substance should not be toxic when running flow through experiment.Same conclusion when running the tool for marine environment where a value of 518,201 mg/L was calculated.
*ECOSAR class for TBPA-anhydride is Neutral Organics (ECOSAR V1.00)
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