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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was well reported, but information on GLP status was missing.
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPPTS 850.1010 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
GLP compliance:
not specified
Analytical monitoring:
no
Vehicle:
yes
Details on test solutions:
Vehicle: acetone. Maximum solubility of test material in acetone (10 mg/ml) limited test levels to 5.6 ppm.
Test organisms (species):
Daphnia magna
Details on test organisms:
Original stock obtained from the National Water Quality Laboratory, Duluth, MN
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Hardness:
60 mg/L as CaC)2
Test temperature:
17 +/- 1 degrees C
pH:
7.31
Nominal and measured concentrations:
0, Solvent Control, and 5 test concentrations up to 5.6 ppm.
Reference substance (positive control):
yes
Remarks:
p,p'-DDT
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 5.6 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Validity criteria fulfilled:
yes
Conclusions:
The 48 hr EC50 in Daphnia magna was > 5.6 mg/L, the highest concentration tested. TBPA undergoes hydrolysis to TBPA-acid. ECOSAR estimates the 48 h EC50 of TBPA-acid in Daphnia to be 15.470 mg/L, which is consistent with the measured EC50 for TBPA of >5.6 mg/L. ECOSAR estimates the water solubility of TBPA-acid to be 4.448 mg/L, which is greater than the 48 h EC50. Based on this, neither TBPA nor its hydrolysis product TBPA-acid are expected to be acutely toxic to Daphnia.
Executive summary:

The 48 hr EC50 in Daphnia magna was > 5.6 mg/L, the highest concentration tested. TBPA undergoes hydrolysis to TBPA-acid. ECOSAR estimates the 48 h EC50 of TBPA-acid in Daphnia to be 15.470 mg/L, which is consistent with the measured EC50 for TBPA of >5.6 mg/L. ECOSAR estimates the water solubility of TBPA-acid to be 4.448 mg/L, which is greater than the 48 h EC50. Based on this, neither TBPA nor its hydrolysis product TBPA-acid are expected to be acutely toxic to Daphnia.


 

Description of key information

48 hr test in Daphnia magna

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
EC50
Effect concentration:
14.961 mg/L

Additional information

The 48 hr EC50 in Daphnia magna was > 5.6 mg/L, the highest concentraiton tested. TBPA undergoes hydrolysis to TBPA-acid. ECOSAR estimates the 48 h EC50 of TBPA-acid in Daphnia to be 14.961 mg/L, which is consistent with the measured EC50 for TBPA of >5.6 mg/L. ECOSAR estimates the water solubility of TBPA-acid to be 0.104 mg/L, which is lower than the 48 h EC50. Based on this, neither TBPA nor its hydrolysis product TBPA-acid are expected to be acutely toxic to Daphnia.