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EC number: 211-185-4 | CAS number: 632-79-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
TBPA: 28 D rabbit dermal; 21 D rat inhalation
TCPA (tetrachlorophthalic anhydride): 13 Wk rat gavage, 13 WK mouse gavage
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 94 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 2 000 mg/m³
- Study duration:
- subchronic
- Species:
- rat
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 500 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rabbit
Additional information
TBPA has been tested in a 28 day rabbit dermal and 21 day rat inhalation studies. In the inhalation study, no adverse effects were noted at 2 mg/L. In the dermal study, all rabbits at the top dose of 5000 mg/kg died or were sacrificed prior to the study's end. The NOAEL for systemic toxicity in that study was the next highest dose, 500 mg/kg. Hisptopathlogy was not performed at the 5000 mg/kg dose, and limited clinical pathology indicated an increase in BUN, and albumin and glucose in the urine. These changes are indicative of an effect on the kidney. TBPA's structural analog, tetrachlorophthalic anhydride or TCPA, has been tested in the rat and mouse in 13 week studies with administration via gavage. Mice were not affected by doses up to 1500 mg/kg. Rats, however, were affected and the LOAEL was 94 mg/kg. Although no clinical pathology changes clearly associated with treatment were observed, rats exhibitied dose-dependent increases in kidney weights and in the incidence and severity of renal tuble necrosis and/or dilation. Thus, TCPA and TBPA appear to be renal toxicants in the rat and rabbit, respectively. Mice, however, appear resistent.
Repeated dose toxicity: via oral route - systemic effects (target organ) urogenital: kidneys
Repeated dose toxicity: dermal - systemic effects (target organ) urogenital: kidneys
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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