Registration Dossier

Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13 Jul 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
GLP guideline study
Cross-reference
Reason / purpose for cross-reference:
reference to other study
Reference
Endpoint:
appearance / physical state / colour
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13 Jul 2016
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given (comparable to guidelines/standards)
Reason / purpose for cross-reference:
reference to other study
Qualifier:
no guideline required
Principles of method if other than guideline:
Visual observation of the test item
GLP compliance:
no
Specific details on test material used for the study:
Storage conditions: Ambient temperature (< 40 °C), keep container tightly closed, protected from sunlight
Physical state at 20°C and 1013 hPa:
solid
Form:
solid: particulate/powder
Remarks:
crystalline powder
Colour:
pale yellow
Substance type:
organic

The test item has a boiling range from 291 °C to 294 °C at atmospheric pressure (1013 hPa). Therefore, at ambient conditions, the test item is solid.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 103 (Boiling Point)
Version / remarks:
adopted in 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
Version / remarks:
adopted in 1996
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
Hess. Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
3,5-di-tert-butyl-4-hydroxybenzyl alcohol
EC Number:
201-815-6
EC Name:
3,5-di-tert-butyl-4-hydroxybenzyl alcohol
Cas Number:
88-26-6
Molecular formula:
C15H24O2
IUPAC Name:
2,6-di-tert-butyl-4-(hydroxymethyl)phenol
Specific details on test material used for the study:
Storage conditions: Ambient temperature (< 40 °C), keep container tightly closed, protected from sunlight

Results and discussion

Boiling point
Boiling pt.:
>= 291 - <= 294 °C
Atm. press.:
1 013 hPa

Any other information on results incl. tables

Results
A first endothermic effect could be seen in the range of 110 to 150 °C (melting) and a second in the range of 210 to 350 °C (boiling).

 

Table 1 – DSC measurement results

Sample weight [mg]

Onset of effect [°C]

Range of effect [°C]

Weight loss [mg]

Atmospheric pressure [hPa]

11.83

140.69
290.90

110 – 150 (endo)
210 – 350 (endo)

11.70

1001.3

11.89

140.94
293.93

130 – 150 (endo)
210 – 350 (endo)

11.85

 

For the correction of the boiling temperature to normal pressure, the test item was assigned to chemical group 5 (e.g. benzyl alcohol). A correction value φ = 5.9 was used for a temperature of 290 °C.

The lowest measured onset temperature is corrected to the normal pressure to be 291.39 °C and the highest onset temperature to be 294.42 °C.

Therefore, the test item has a boing range of 291 to 294 °C under atmospheric pressure (1013 hPa).

Applicant's summary and conclusion