Registration Dossier
Registration Dossier
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EC number: 205-448-2 | CAS number: 141-02-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline available at the study performance date.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List V
- Author:
- Smyth HF
- Year:
- 1 954
- Bibliographic source:
- Archives of Industrial Hygiene and Occupational Medicine vol 10, pp 61-68
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Bis(2-ethylhexyl) fumarate
- EC Number:
- 205-448-2
- EC Name:
- Bis(2-ethylhexyl) fumarate
- Cas Number:
- 141-02-6
- Molecular formula:
- C20H36O4
- IUPAC Name:
- bis(2-ethylhexyl) but-2-enedioate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- body weights: 90-120 g
food: Rockland rat diet
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- animals non-fasted
dosages arranged in a logarithmic series differing by a factor of 2
observation period: 14 days p.a. - Statistics:
- Method of Thompson-Weil for the calculation of the LD50 value
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 29 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50, oral, rat was 29.2 g per kg body weight when administered by gavage.
- Executive summary:
The test substance was administered to groups of 5 rats each. Mortality was recorded during an observation period of 14 days p.a. The LD50, calculated by the method of Thompson and Weil, was 29.2 g per kg body weight.
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