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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline available at the study performance date.

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List V
Author:
Smyth HF
Year:
1954
Bibliographic source:
Archives of Industrial Hygiene and Occupational Medicine vol 10, pp 61-68

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-ethylhexyl) fumarate
EC Number:
205-448-2
EC Name:
Bis(2-ethylhexyl) fumarate
Cas Number:
141-02-6
Molecular formula:
C20H36O4
IUPAC Name:
bis(2-ethylhexyl) but-2-enedioate
Details on test material:
no data

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
not specified
Details on test animals or test system and environmental conditions:
body weights: 90-120 g
food: Rockland rat diet

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
animals non-fasted
dosages arranged in a logarithmic series differing by a factor of 2
observation period: 14 days p.a.
Statistics:
Method of Thompson-Weil for the calculation of the LD50 value

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
29 200 mg/kg bw
Based on:
test mat.
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50, oral, rat was 29.2 g per kg body weight when administered by gavage.
Executive summary:

The test substance was administered to groups of 5 rats each. Mortality was recorded during an observation period of 14 days p.a. The LD50, calculated by the method of Thompson and Weil, was 29.2 g per kg body weight.