Registration Dossier
Registration Dossier
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EC number: 219-943-6 | CAS number: 2580-56-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Reliability 4 has been assigned due to the lack of information on the composition of test substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
- Principles of method if other than guideline:
- Not available.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Basic Blue 026 chloride
- IUPAC Name:
- Basic Blue 026 chloride
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Aqueous suspension: 16 - 30 %
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 600 mg/kg bw
- Based on:
- test mat.
- Other findings:
- Dyspnoea, discolouration of faeces and urine. Discolouration in content of gastrointestinal tract and of the whole coat of hair.
Applicant's summary and conclusion
- Interpretation of results:
- other: acute oral toxicity cat. 4, according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- LD50 in rat = ca. 1600 mg/kg
- Executive summary:
Method
Test substance in aqueous suspension (16 and 30 %) was administered once by gavage to rats. Upon a 7 -day observation period, sacrifice and necropsy of surviving animals was carried out.
Results
LD50 = 1600 mg/kg.
Other observations: dyspnoea, discolouration of faeces and urine; discolouration in content of gastrointestinal tract and of the whole coat of hair.
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