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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
Reliability 4 has been assigned due to the lack of information on the composition of test substance.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report Date:
1967

Materials and methods

Principles of method if other than guideline:
Not available.
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Test animals

Species:
rat
Strain:
Sprague-Dawley

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
Aqueous suspension: 16 - 30 %
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 600 mg/kg bw
Based on:
test mat.
Other findings:
Dyspnoea, discolouration of faeces and urine. Discolouration in content of gastrointestinal tract and of the whole coat of hair.

Applicant's summary and conclusion

Interpretation of results:
other: acute oral toxicity cat. 4, according to the CLP Regulation (EC 1272/2008)
Conclusions:
LD50 in rat = ca. 1600 mg/kg
Executive summary:

Method

Test substance in aqueous suspension (16 and 30 %) was administered once by gavage to rats. Upon a 7 -day observation period, sacrifice and necropsy of surviving animals was carried out.

Results

LD50 = 1600 mg/kg.

Other observations: dyspnoea, discolouration of faeces and urine; discolouration in content of gastrointestinal tract and of the whole coat of hair.