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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data from secondary source

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Rosin and Rosin Salts Category - Supporting Documents for Initial Risk-Based Prioritization
Author:
U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxics (OPPT) Risk Assessment Division (RAD)
Year:
2008
Bibliographic source:
Rosin and Rosin Salts Category - Supporting Documents for Initial Risk-Based Prioritization, 2008
Reference Type:
secondary source
Title:
IUCLID dataset for the CAS: 65997-06-0
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID dataset for the CAS: 65997-06-0; EUROPEAN COMMISSION – European Chemicals Bureau; 2000
Reference Type:
secondary source
Title:
Acute oral toxicity study in Rat for CAS no: 65997-06-0
Author:
RTECS
Year:
2017
Bibliographic source:
RTECS (registry of toxic effect of chemical substance data base ), 2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Acute oral toxicity study of Rosin hydrogenated was performed in Rat
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
Rosin, hydrogenated
EC Number:
266-041-3
EC Name:
Rosin, hydrogenated
Cas Number:
65997-06-0
IUPAC Name:
Rosin hydrogenated
Details on test material:
- Name of test material (as cited in study report):Rosin hydrogenated
- Molecular formula :Unspecified
- Molecular weight :Unspecified
- Substance type:organic
- Physical state:No data available
-Purity:No data available
- Impurities (identity and concentrations):No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report):Rosin hydrogenated
- Molecular formula :Unspecified
- Molecular weight :Unspecified
- Substance type:organic
- Physical state:No data available
-Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
31500 mg/kg bw
No. of animals per sex per dose:
Total:20
Male:10
Female:10
Control animals:
not specified
Details on study design:
Details on study design
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: No data available
- Other examinations performed: No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 31 500 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be >31500mg/kg body weight. When wistar rats were treated with Rosin hydrogenated (65997-06-0) orally.
Executive summary:

Acute oral toxicity study was done in wistar rat usingRosin hydrogenated (65997-06-0).10 male and 10 female rats were administered with test material in dose concentration 31500mg/kg bw and observed for14 days .No mortality was observed .HenceLD50 was considered to be >31500mg/kgbody weight. When wistar rats were treated withRosin hydrogenated (65997-06-0) orally.