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Description of key information

The substance cyclododecanol tel quel represents a reaction mass consisting of cyclododecanol and cyclododecanone. No studies regarding acute toxicity were made with the reaction mass. However studies with the components cyclododecanol and cyclododecanone were performed. These studies were used in a read across approach. It is concluded that the reaction mass cyclododecanol tel quel consisting of cyclododecanol and cyclododecanone is considered to be of low oral acute toxicity too and the LD50: > 2500 mg/kg bw d is also relevant for the reaction mass cyclododecanol tel quel. There are no valid acute inhalation and dermal studies available.

Key value for chemical safety assessment

Additional information

The substance cyclododecanol tel quel represents a reaction mass consisting of cyclododecanol and cyclododecanone. No studies regarding acute toxicity were made with the reaction mass. However studies with the components cyclododecanol and cyclododecanone were performed. These studies were used in a read across approach.

Oral acute toxicity:

Cyclododecanol and cyclododecanone showed low acute oral toxicity in studies conducted with rats (LD50: > 2500 mg/kg bw d). These findings were supported in studies conducted with cyclododecanol and cyclododecanone in mice. Hence it is concluded that the reaction mass cyclododecanol tel quel consisting of cyclododecanol and cyclododecanone is considered to be of low oral acute toxicity too. It is concluded that the LD50: > 2500 mg/kg bw d is also relevant for the reaction mass cyclododecanol tel quel.

Inhalation acute toxicity:

There are no valid acute inhalation studies available.

Dermal acute toxicity:

There are no valid acute dermal studies available

Justification for classification or non-classification

According to the criteria of EC Directive 67/548/EEC and EC Regulation 1272/2008 and based on the results of the studies the substance cyclododecanol tel quel is not classified regarding this endpoint.