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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
09/1964
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964

Materials and methods

Test guideline
Qualifier:
no guideline followed
Deviations:
not applicable
Principles of method if other than guideline:
Farbenfabrik Bayer AG
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclododecanol
EC Number:
217-031-2
EC Name:
Cyclododecanol
Cas Number:
1724-39-6
Molecular formula:
C12H24O
IUPAC Name:
cyclododecanol
Details on test material:
TS: "pure" cyclododecanol, no further information

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no details

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: acetone + vegetable oil (1:10)
Details on oral exposure:
ADMINISTRATION: 
- Doses per time period: single dose (gavage)
- Volume administered or concentration: 5 ml/kg bw
Doses:
1000; 1500; 2000; 2500 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Post dose observation period: 7 days
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 500 mg/kg bw
Mortality:
MORTALITY: No deaths occurred
Clinical signs:
CLINICAL SIGNS: No signs of toxicity were observed in the 1000 mg/kg bw  group. All other treated animals showed increased respiratory rate and  
imparied general condition.
Body weight:
no data
Gross pathology:
no data
Other findings:
no other findings

Any other information on results incl. tables

DOSE  [mg/kg bw]    MORTALITY/CLINICAL SIGNS/ANIMALS PER DO

------------------------------------------------------------------------

1000                          0/ 0/10

1500                          0/10/10

2000                          0/10/10

2500                          0/10/10


Applicant's summary and conclusion

Conclusions:
Under the conditions of this study the acute oral toxicity of Cyclododecanol is very low in rats. The derived LD50 is greater than 2500 mg/kg of
body weight.
Executive summary:

The test item Cyclododecanol was applied by oral gavage once to 4 dose-groups of 10 rats in doses of 1000; 1500; 2000 and 2500 mg/kg bw as solution in acetone/vegetable oil 1:10. The observation period was 7 days, there was no mortality. No clinical signs were observed in the 1000 mg/kg bw group,  all other treated animals showed increased respiratory rate and   imparied general condition. Under the conditions of this study the acute oral toxicity of Cyclododecanol is very low in rats. The derived LD50 is greater than 2500 mg/kg of body weight.