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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two toxicity to micro-organism studies as-
2. and 3.
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: 2. Pseudomonas fluorescens and 3. Pseudomonas putida
Test type:
not specified
Water media type:
freshwater
Total exposure duration:
24 h
Reference substance (positive control):
not specified
Duration:
24 h
Dose descriptor:
EC0
Effect conc.:
500 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: 2. No effect were observed on multiplication of bacterial cells.
Duration:
17 h
Dose descriptor:
EC10
Effect conc.:
140 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: 3.
Duration:
17 h
Dose descriptor:
EC50
Effect conc.:
190 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: 3.
Duration:
17 h
Dose descriptor:
other: EC90
Effect conc.:
240 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: 3.
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 190 mg/l, respectively.
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms.The studies are as mentioned below:

Short term toxicity to Pseudomonas fluorescens study was carried out for 24 hr.The study was based on the effects of the test chemical on Pseudomonas fluorescens. Pseudomonas fluorescens was used as a test organism. On the basis of the effect of test chemical on growth rate, i.e, multiplication of the test organism Pseudomonas fluorescens, the 24 h EC0 value was determined to be 500 mg/l.

Another short term toxicity to Pseudomonas putida study was carried out for 17 hr.The study was based on the effects of the test chemical on Pseudomonas putida. Pseudomonas putida was used as a test organism. On the basis of the effect of test chemical on growth rate, i.e, cell multiplication of the test organism Pseudomonas putida, the 17 h EC10, EC50 and EC90 value was determined to be 140, 190 and 240 mg/l, respectively.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 190 mg/l, respectively.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 190 mg/l, respectively.

Key value for chemical safety assessment

EC50 for microorganisms:
190 mg/L

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms. The studies are as mentioned below:

 

Short term toxicity to Pseudomonas fluorescens study was carried out for 24 hr. The study was based on the effects of the test chemical on Pseudomonas fluorescens. Pseudomonas fluorescens was used as a test organism. On the basis of the effect of test chemical on growth rate, i.e, multiplication of the test organism Pseudomonas fluorescens, the 24 h EC0 value was determined to be 500 mg/l.

 

Another short term toxicity to Pseudomonas putida study was carried out for 17 hr. The study was based on the effects of the test chemical on Pseudomonas putida. Pseudomonas putida was used as a test organism. On the basis of the effect of test chemical on growth rate, i.e, cell multiplication of the test organism Pseudomonas putida, the 17 h EC10, EC50 and EC90 value was determined to be 140, 190 and 240 mg/l, respectively.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 190 mg/l, respectively.