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Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute oral toxicity by using test chemical
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
ChemIDplus

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of the given test chemical on rats.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
Sodium naphthalene-2-sulphonate
EC Number:
208-523-8
EC Name:
Sodium naphthalene-2-sulphonate
Cas Number:
532-02-5
IUPAC Name:
sodium naphthalene-2-sulfonate
Details on test material:
- Name of test material (IUPAC name): Sodium naphthalene-2-sulphonate
- Common name: Sodium 2-naphthalenesulfonate
- Molecular formula: C10H7NaO3S
- Molecular weight: 230.2183 g/mol
- Smiles notation: c1ccc2cc(ccc2c1)S(=O)(=O)[O-].[Na+]
- InChl: 1S/C10H8O3S.Na/c11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10;/h1-7H,(H,11,12,13);/q;+1/p-1
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):Sodium 2-naphthalenesulfonate
- Molecular formula :C10H7NaO3S
- Molecular weight :230.2183 g/mol
- Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
13900 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
13 900 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% Mortality was observed at dose 13900 mg/kg bw.
Mortality:
50% Mortality was observed at dose 13900 mg/kg bw.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 13900 mg/kg bw, when rats were treated with the given test chemical orally.
Executive summary:

Acute oral toxicity study was conducted by using the given test chemical in rats at the dose concentration of 13900 mg/kg bw via oral route. Animals were observed for mortality. 50% Mortality was observed at dose 13900 mg/kg bw. Hence, the lethal concentration (LD50) value for acute oral toxicity test was considered to be 13900 mg/kg bw, when rats were treated with the given test chemical orally.