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EC number: 202-219-9 | CAS number: 93-11-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary report.
Data source
Reference
- Reference Type:
- other: secondary source
- Title:
- SIDS Initial Assessment Report for 4-Methylbenzenesulfonyl chloride
- Author:
- United Nations Environmental Programme (UNEP)
- Year:
- 2 003
- Bibliographic source:
- SIDS Initial Assessment Report for 4-Methylbenzenesulfonyl chloride , United Nations Environmental Programme (UNEP) 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- To evaluate skin irritation potential of the given test chemical on new Zealand white rabbit.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-Methylbenzenesulfonyl chloride
- Cas Number:
- 98-59-9
- Molecular formula:
- C7H7ClO2S
- IUPAC Name:
- 4-Methylbenzenesulfonyl chloride
- Details on test material:
- IUPAC name-4-Methylbenzenesulfonyl chloride
Molecular formula :C7H7ClO2S
Molecular weight :190.65 g/mol
Substance type: Organic
Physical state:solid
Smiles :S(=O)(=O)(c1ccc(cc1)C)Cl
InChI :1S/C7H7ClO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3
Constituent 1
- Specific details on test material used for the study:
- IUPAC name-4-Methylbenzenesulfonyl chloride
Molecular formula :C7H7ClO2S
Molecular weight :190.65 g/mol
Substance type: Organic
Physical state:solid
Smiles :S(=O)(=O)(c1ccc(cc1)C)Cl
InChI :1S/C7H7ClO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3
Purity: 99.7%
Impurities:≤0.1%
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- - Age at study initiation: 3-4 months old
-Number of animals: 3 animals
-Weight at study initiation: 2.1 - 2.3 kg
-Sex: Male animals
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- not specified
- Controls:
- yes
- Amount / concentration applied:
- 500mg in 0.1 ml sterile distilled water
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 1, 24, 48 and 72 hours
- Number of animals:
- total = 3
- Details on study design:
- - Area of exposure: (2.5 x 2.5 cm)
-Type of wrap if used: three fold gauze patches
- Washing (if done): washed using warm water
- SCORING SYSTEM: Used (OECD method – Grading of skin reaction)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 22
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 15
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- erythema, scab and oedema were observed at the abraded and intact skins on the backs of three rabbits.
Any other information on results incl. tables
Change Erythema and Eschar |
||||||||
Applicated area |
Intact |
Abrarded |
||||||
Phase (hrs) |
1 |
24 |
48 |
72 |
1 |
24 |
48 |
72 |
Animal ID (M01) |
2 |
3 |
3 |
3 |
2 |
3 |
3 |
3 |
M02 |
2 |
3 |
3 |
3 |
2 |
3 |
3 |
3 |
M03 |
2 |
3 |
3 |
3 |
2 |
3 |
3 |
3 |
Total |
6 |
9 |
9 |
9 |
6 |
9 |
9 |
9 |
Mean |
2.0 |
3.0 |
3.0 |
2.0 |
3.0 |
3.0 |
3.0 |
3.0 |
Total of mean |
22.0 |
Change Edema |
||||||||
Applicated area |
Intact |
Abrarded |
||||||
Phase (hrs) |
1 |
24 |
48 |
72 |
1 |
24 |
48 |
72 |
Animal ID (M01) |
1 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
M02 |
1 |
3 |
2 |
2 |
3 |
2 |
2 |
2 |
M03 |
1 |
2 |
2 |
1 |
2 |
2 |
2 |
1 |
Total |
3 |
7 |
6 |
5 |
6 |
7 |
6 |
5 |
Mean |
1.0 |
2.3 |
2.0 |
1.7 |
2.0 |
2.3 |
2.0 |
1.7 |
Total of mean |
15.0 |
Erythema and Eschar formation
0 – No erythema
1 – Very slight erythema (barely perceptible)
2 – Well defined erythema
3 – Moderate to severe erythema
4–Severe erythema (beef redness) to eschar formation preventing grading of erythema
- edema formation
0 – No oedema
1 – Very slight oedema (barely perceptible)
2 – Slight oedema (edges of area well defined by definite raising)
3 – Moderate oedema (raised approximately 1 mm)
4 – Severe oedema (raised more than 1 mm and extending beyond area of exposure)
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The given test chemical was applied on the rabbit’s back in concentration 500 mg . Erythema, scab and edema were observed at the abraded and intact skins on the backs of three rabbits.Hence, it is considered to be moderately irritating
- Executive summary:
The given test chemical was used to evaluate its skin irritation potential on New Zealand White rabbits. 500 mg of test material with about 0.1 mL of sterile distilled water was applied on abraded and intact sites on the shaved backs (2.5 x 2.5 cm) of rabbits. Left side of the back was treated as control. It was held in place for 4 hours with three fold gauze patches, which was applied in place with elasticity bandage then was fixed with non-irritating tape (3M paper-tape). After 4 hours, three fold gauze patches were removed and the exposed areas washed using warm water without altering the existing response or the integrity of the epidermis. The skin of animals was examined in accordance with an OECD scoring method for signs of erythema and oedema and the responses scored at 1, 24, 48 and 72 hours after the patches removal. Test chemical was applied on the rabbit’s back in concentration 500 mg. Erythema, scab and edema were observed at the abraded and intact skins on the backs of three rabbits. Hence, it is considered to be moderately irritating.
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