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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from IUCLID Dataset.

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID Dataset of CAS 760-67-8
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID Dataset, EUROPEAN COMMISSION – European Chemicals Bureau, 19 – FEB - 2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute dermal toxicity of 2-ethylhexanoyl chloride (760-67-8) in rabbits.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexanoyl chloride
EC Number:
212-081-1
EC Name:
2-ethylhexanoyl chloride
Cas Number:
760-67-8
Molecular formula:
C8H15ClO
IUPAC Name:
2-ethylhexanoyl chloride
Details on test material:
- IUPAC Name: 2–ethylhexanoyl chloride
- Mol. formula: C8H15ClO
- Molecular Weight: 162.658 g/mole
- Smiles: C(=O)(Cl)[C@@H](CC)CCCC
- InChI: 1S/C8H15ClO/c1-3-5-6-7(4-2)8(9)10/h7H,3-6H2,1-2H3
Specific details on test material used for the study:
- IUPAC Name: 2–ethylhexanoyl chloride
- Mol. formula: C8H15ClO
- Molecular Weight: 162.658 g/mole
- Smiles: C(=O)(Cl)[C@@H](CC)CCCC
- InChI: 1S/C8H15ClO/c1-3-5-6-7(4-2)8(9)10/h7H,3-6H2,1-2H3

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
2010 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 010 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed at 2010 mg/kg bw
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 was considered to be > 2010 mg/kg bw, when rabbits were treated with 2-ethylhexanoyl chloride (760-67-8) by dermal application.
Executive summary:

The acute dermal toxicity of 2-ethylhexanoyl chloride was tested in rabbits at the concentration of 2010 mg/kg bw. No mortality was observed at 2010 mg/kg bw. Therefore, LD50 was considered to be > 2010 mg/kg bw, when rabbits were treated with 2-ethylhexanoyl chloride (760-67-8) by dermal application.