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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from handbook

Data source

Reference
Reference Type:
review article or handbook
Title:
α-Methyl styrene [MAK Value Documentation, 2001]
Author:
The MAK Collection for Occupational Health and Safety
Year:
2012
Bibliographic source:
The MAK Collection for Occupational Health and Safety, 138–140, 2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation study of 2-Phenylpropene was conducted on shaved rabbit skin to assess its irritation efficacy.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenylpropene
EC Number:
202-705-0
EC Name:
2-phenylpropene
Cas Number:
98-83-9
Molecular formula:
C9H10
IUPAC Name:
2-Phenylpropene
Test material form:
liquid
Details on test material:
Name of the test chemical: 2-Phenylpropene
Molecular Weight: C9H10
Molecular Formula: 118.178 g/mol
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical: 2-Phenylpropene
Molecular Weight: C9H10
Molecular Formula: 118.178 g/mol
Substance Type: Organic
Physical State: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
100% (undiluted)
Duration of treatment / exposure:
2 -4 weeks (10-20 applications)
Observation period:
2 -4 weeks
Number of animals:
no data available
Details on study design:
-Type of wrap if used: bandage

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: weeks
Reversibility:
not specified
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
Moderate to severe irritation and slight necrosis was observed

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The rabbits showed moderate to severe irritation and slight necrosis was also observed. Hence the test chemical 2-Phenylpropene (CAS No:- 98-83-9)was considered to be irritating to the shaved skin of rabbits.
Executive summary:

A Skin irritation study was carried out inrabbitsto assess the irritation potency of 2-Phenylpropene(CAS No:- 98-83-9).Undiluted test chemical was applied to the shaved skin of rabbits skin under a bandage for 2 to 4 weeks (10 to 20 applications).

The rabbits showed moderate to severe irritation and slight necrosis was also observed. Hence, the test chemical 2-Phenylpropene(CAS No:- 98-83-9)was considered to be irritating to the shaved skin of rabbits.