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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Reference
Reference Type:
other: authoritative database
Title:
Eye Irritation of 532-32-1
Author:
IFA (GESTIS)
Year:
2017
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften), 2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate the ocular irritation potential of Sodium benzoate in humans
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium benzoate
EC Number:
208-534-8
EC Name:
Sodium benzoate
Cas Number:
532-32-1
Molecular formula:
C7H6O2.Na
IUPAC Name:
Sodium Benzoate
Test material form:
solid
Details on test material:
Name of the test chemical:Sodium benzoate
Molecular formula:C7H5O2Na
Molecular weight: 144.11 g/mol
Substance type: organic
Physical state: Solid
Specific details on test material used for the study:
Name of the test chemical:Sodium benzoate
Molecular formula:C7H5O2Na
Molecular weight: 144.11 g/mol
Substance type: organic
Physical state: Solid

Test animals / tissue source

Species:
other: humans
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
No data available
Observation period (in vivo):
No data available
Duration of post- treatment incubation (in vitro):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available

Results and discussion

In vitro

Other effects / acceptance of results:
No data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: No data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation observed
Other effects:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Under the conditions of the study, sodium benzoate was not irritating to human eyes.
Executive summary:

The ocular irritation potential of Sodium benzoate was evaluated in humans.

Sodium benzoate was instilled into human eyes and effects were observed (dose and duration not specified).

Under the conditions of the study, sodium benzoate was not irritating to human eyes.