Registration Dossier
Registration Dossier
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EC number: 204-072-6 | CAS number: 115-21-9
Endpoint summary
Administrative data
Description of key information
The one-hour combined male/female LC50 (nominal concentrations) was determined to be 1257 ppm with 95% confidence limits of 1175-1320 ppm in rats (Dow Corning Corporation, 1997). There are no reliable data for the oral and dermal routes, and the corrosive nature of trichloro(ethyl)silane means that the acute oral toxicity study (required in Section 8.5.1) does not need to be conducted.
Key value for chemical safety assessment
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 4 200 mg/m³
Additional information
The only available reliable study was selected as the key inhalation study. No reliable data are available for the oral or dermal routes, although supporting data are available for acute oral toxicity.
The inhalation LC50 is 1257 ppm from a one hour exposure period. When this value is adjusted (divided by 2) to account for the short exposure duration, the LC50 becomes 628 ppm (converting from 1 -hour LC50 to 4 -hour LC50, which is the relevant value for classification), which is equivalent to approximately 4.2 mg/l (4200 mg/m3).
Justification for classification or non-classification
On the basis of the available measured LD(C)50values, trichloro(ethyl)silane is classified R20/22 'Harmful by inhalation and if swallowed', according to the criteria of EU Directive 67/548/EEC and 'Acute toxic 4 (oral)', and 'Acute toxic 3 (vapour)' under Regulation 1272/2008.
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