Registration Dossier
Registration Dossier
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EC number: 204-072-6 | CAS number: 115-21-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study did not meet current guideline requirements for acute oral toxicity. It does however add weight of evidence for acute toxicity of trichloro(ethyl)silane.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Report date:
- 1951
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No information available.
- GLP compliance:
- not specified
- Test type:
- other:
Test material
- Reference substance name:
- Trichloro(ethyl)silane
- EC Number:
- 204-072-6
- EC Name:
- Trichloro(ethyl)silane
- Cas Number:
- 115-21-9
- Molecular formula:
- C2H5Cl3Si
- IUPAC Name:
- trichloro(ethyl)silane
- Details on test material:
- - Name of test material (as cited in study report): Trichloroethylsilane
- Substance type: CHLORO-Si (TRI-Cl)
- Physical state: colourless liquid
- Storage condition of test material: To be stored in a cool, well ventilated location. Separate from acids, alkalies, oxidizing materials and water.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 330 mg/kg bw
- Remarks on result:
- other: in rat
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 value of 1300 mg/kg was determined in a study which did not meet current guideline requirements for acute oral toxicity. It does, however, add weight of evidence for trichloro(ethyl)silane toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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