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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study did not meet current guideline requirements for acute oral toxicity. It does however add weight of evidence for acute toxicity of trichloro(ethyl)silane.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1951
Report date:
1951

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No information available.
GLP compliance:
not specified
Test type:
other:

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloro(ethyl)silane
EC Number:
204-072-6
EC Name:
Trichloro(ethyl)silane
Cas Number:
115-21-9
Molecular formula:
C2H5Cl3Si
IUPAC Name:
trichloro(ethyl)silane
Details on test material:
- Name of test material (as cited in study report): Trichloroethylsilane

- Substance type: CHLORO-Si (TRI-Cl)

- Physical state: colourless liquid

- Storage condition of test material: To be stored in a cool, well ventilated location. Separate from acids, alkalies, oxidizing materials and water.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 330 mg/kg bw
Remarks on result:
other: in rat

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value of 1300 mg/kg was determined in a study which did not meet current guideline requirements for acute oral toxicity. It does, however, add weight of evidence for trichloro(ethyl)silane toxicity.