Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 290-649-8 | CAS number: 90194-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
There are no experimental data available for the substance itself in regards to PBT properties. However, a read-across approach is applied taking into account the respective constituents of the test item as well as a similar composed UVCB substance. Therefore, PBT properties of the source substances are considered to adequately reflect the test items PBT properties. For more detailed information on the read-across apporach please refer to read-across justification attached to IUCLID section 13.
All source substances were found to be readily biodegradable. Therefore, there is no evidence that the test item could not be readily biodegradable.
LAS Na (Source substance 2) was demonstrated to not have a potential for bioaccumulation in a respective study.
Based on its physico-chemical properties, DEA (source substance 3) would also not be considered to be bioaccumulative. However, respective toxicokinetic studies revealed an accumulation in liver and kidney with an elimination half-life of 6 days. Mechanistically, a missuse of DEA in the endogenous phospholipid pathway is assumed.
Concluding, the test item itself is not considered as substantially bioaccumulative.
Regarding toxicity, LAS Na is neither classified as CMR nor as STOT RE according to Regulation (EC) No 1272/2008.
Based on available acute aquatic toxicity studies, lowest EC50 was determined to be 1.67 mg/L for LAS Na and EC50 of 5.7 mg/L for DEA, respectively, with fish as most sensitive species in both cases. Thus, the screening criteria threshold value of 0.01 mg/L is not met.
DEA is not considered as CMR, but classified as STOT RE 2 under Regulation (EC) No 1272/2008. As DEA is considered to be a constituent of the test item > 10 % and there is no experimental data available with the test item itself, it is also classified as STOT RE 2 (please refer to IUCLID section 7.5 for repeated dose toxicity). Therefore, the T criterion applies.
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