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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient documentation for an assessment of reliability.

Data source

Reference
Reference Type:
study report
Title:
Unnamed

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
EC Number:
603-689-1
Cas Number:
132961-05-8
Molecular formula:
C23H28F2N4O2
IUPAC Name:
3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
No data

Results and discussion

Solubility in organic solvents / fat solubilityopen allclose all
Medium:
methanol
Solubility:
5.4 g/L
Temp.:
20 °C
Medium:
ethanol
Solubility:
2.7 g/L
Temp.:
20 °C
Medium:
isopropanol
Solubility:
4.1 g/L
Temp.:
20 °C
Medium:
other: dichloromethane
Solubility:
6.5 g/L
Temp.:
20 °C
Medium:
other: 2-propanone
Solubility:
3.1 g/L
Temp.:
20 °C
Medium:
ethyl acetate
Solubility:
1.6 g/L
Temp.:
20 °C
Medium:
other: hexane
Solubility:
< 0.01 g/L
Temp.:
20 °C
Medium:
other: methylbenzene
Solubility:
0.48 g/L
Temp.:
20 °C
Medium:
other: 4-methyl-2-pentanone
Solubility:
1.9 g/L
Temp.:
20 °C
Medium:
other: 2-butanone
Solubility:
2.7 g/L
Temp.:
20 °C
Details on results:
no data

Any other information on results incl. tables

Table 1 Solubility of the T001624 at 20 deg C

 Solvent  Solubility in g/L solution
 tetrahydrofuran  7.4
1 -methoxy-2-propanol   15
 N,N-dimethylacetamide  59
 acetic acid  > 300
 1,1'-oxybisethane  0.42
 N,N-dimethylformamide  37
 sulfinylbismethane  28
 2,2'-oxybispropane  0.02
 dichloromethan/methanol (10/90 v/v)  12
 dichloromethan/methanol (20/80 v/v)  25
 dichloromethan/methanol (30/70 v/v)  53
 dichloromethan/methanol (40/60 v/v)  110
 dichloromethan/methanol (50/50 v/v)  180

Applicant's summary and conclusion