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EC number: 603-689-1 | CAS number: 132961-05-8
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9 September 1991 - 24 September 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
- EC Number:
- 603-689-1
- Cas Number:
- 132961-05-8
- Molecular formula:
- C23H28F2N4O2
- IUPAC Name:
- 3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Batch RT001624BEA011 (lot n° 00096624)
HPLC purity 99.3%
Results and discussion
Water solubility
- Key result
- Water solubility:
- 0.121 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 0.55 g/L
- Incubation duration:
- >= 48 - <= 96 h
- Temp.:
- 20 °C
- pH:
- 8.9
- Remarks on result:
- other: 1 to 3 days equilibration and 1 day re-equilibration
- Details on results:
- Preliminary test
Solubility at 20°C: 0.112 g test substance/L solution
Test procedure
Sample I: 0.122 g/L solution (pH 8.9)
Sample II: 0.119 g/L solution (pH 8.9)
Sample III: 0.122 g/L solution (pH 8.9)
Any other information on results incl. tables
The purity of the test substance has not been taken into account
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the test substance was determined via OECD Guideline 105 and at 20°C (and pH 8.9) was determined to be 0.121 g/L.
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