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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
no
Test type:
other: No data

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
EC Number:
603-689-1
Cas Number:
132961-05-8
Molecular formula:
C23H28F2N4O2
IUPAC Name:
3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
Test material form:
solid: particulate/powder

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data
Doses:
640 mg/kg bw
160 mg/kg bw
40 mg/kg bw
No. of animals per sex per dose:
5 rats per dose
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Dose descriptor:
LD50
Effect level:
129.9 mg/kg bw
95% CL:
75.3 - 224.1
Mortality:
640 mg/kg bw: 5/5 mortality immediately after administration
160 mg/kg bw: 4/5 mortality 1 hour after administration
40 mg/kg bw: 0/5 mortality
Clinical signs:
other: 40 mg/kg bw: no changes in behaviour
Body weight:
other body weight observations
Remarks:
No data
Gross pathology:
No data
Other findings:
No data

Any other information on results incl. tables

Not applicable

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The oral LD50-value of substance T001624 is 129.9 (75.3 - 224.1) mg/kg bw.
Executive summary:

Not applicable