Registration Dossier
Registration Dossier
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EC number: 603-689-1 | CAS number: 132961-05-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
- Test type:
- other: No data
Test material
- Reference substance name:
- 3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
- EC Number:
- 603-689-1
- Cas Number:
- 132961-05-8
- Molecular formula:
- C23H28F2N4O2
- IUPAC Name:
- 3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- 640 mg/kg bw
160 mg/kg bw
40 mg/kg bw - No. of animals per sex per dose:
- 5 rats per dose
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 129.9 mg/kg bw
- 95% CL:
- 75.3 - 224.1
- Mortality:
- 640 mg/kg bw: 5/5 mortality immediately after administration
160 mg/kg bw: 4/5 mortality 1 hour after administration
40 mg/kg bw: 0/5 mortality - Clinical signs:
- other: 40 mg/kg bw: no changes in behaviour
- Body weight:
- other body weight observations
- Remarks:
- No data
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
Not applicable
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The oral LD50-value of substance T001624 is 129.9 (75.3 - 224.1) mg/kg bw.
- Executive summary:
Not applicable
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