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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Remarks:
Smith article: Range-finding toxicity data: list VI + Merck index
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1962
Report date:
1962
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single oral dose toxicity is estimated by the gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, 4-5 weeks of age and 90-120 grams in weight. The dosages are arranged in a logarithmic seeries differing by a factor of two.
GLP compliance:
no
Test type:
other: single dose oral toxicity

Test material

1
Chemical structure
Reference substance name:
Indole
EC Number:
204-420-7
EC Name:
Indole
Cas Number:
120-72-9
Molecular formula:
C8H7N
IUPAC Name:
1H-indole
Test material form:
solid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 1 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
H302 Acute tox 4 oral
Executive summary:

LD50 oral rat = 1000 mg/kg bw