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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1962
Report date:
1962
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Penetration of rabbit skin is estimated by a technique losely akin to the one-day cuff method of Draize and associates, using groups of four male albino New Zealand rabbits weighing 2.5-3.5 kg.
GLP compliance:
no

Test material

1
Chemical structure
Reference substance name:
Indole
EC Number:
204-420-7
EC Name:
Indole
Cas Number:
120-72-9
Molecular formula:
C8H7N
IUPAC Name:
1H-indole
Test material form:
solid

Test animals

Species:
rabbit
Strain:
other: New Zealand albino
Sex:
male
Details on test animals or test system and environmental conditions:
4 rabbits were tested.

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 790 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
H311 Acute tox dermal cat 3
Executive summary:

LD 50 dermal rat = 790 mg/kg bw