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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data from secondary source

Data source

Reference
Reference Type:
other: Secondary Literature
Title:
HPVIS- Acute oral toxicity for the test chemical
Author:
HPVIS
Year:
2020
Bibliographic source:
HPVIS, 2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An acute toxicity study of the test chemical was carried out in rats to determine its LD50.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chlorotoluene
EC Number:
203-397-0
EC Name:
4-chlorotoluene
Cas Number:
106-43-4
Molecular formula:
C7H7Cl
IUPAC Name:
1-chloro-4-methylbenzene
Test material form:
solid
Details on test material:
Name of the test chemical: Benzene, 1-chloro-4-methyl-
Molecular Formula: C7H7Cl
Molecular Weight: 126.585 g/mol
Substance Type: Organic
Physical State: Solid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
Age: adult
Weight at study initiation: 205-240 gram averages/dose group

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
no data available
Doses:
2000, 2510, 3160, 3980 and 5010 mg/kg
No. of animals per sex per dose:
5 rats/ dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: on day 1 and day 14
- Necropsy of survivors performed: yes/no:No data available
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:No data available
Statistics:
no data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 350 mg/kg bw
Based on:
test mat.
95% CL:
> 2 090 - < 2 620
Mortality:
50% mortality was not observed at 2350 mg/kg
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The LD50 values were considered to be (with 95% confidence limits) 2350 (2060-2620) mg/kg in males and in females when Sprague Dawley rats were treated with the test chemical orally.
Executive summary:

An acute toxicity study of the test chemical was carried out in male and female Sprague Dawley rats to determine its LD50. 5 male and female rats were dosed with 2000, 2510, 3160, 3980 and 5010 mg/kg of the test chemical orally via gavage. The treated rats were observed for mortality and other effects till 14 days. The LD50 values were considered to be (with 95% confidence limits) 2350 (2060-2620) mg/kg in males and in females when Sprague Dawley rats were treated with the test chemical orally.