Registration Dossier
Registration Dossier
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EC number: 203-750-9 | CAS number: 110-26-9
Carcinogenicity
Administrative data
Description of key information
In a lifetime drinking water study using an unbalanced design in F344 rats, acrylamide induced benign thyroid, mammary gland and tunica vaginalis tumours.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 0.5 mg/kg bw/day
Justification for classification or non-classification
R45
Additional information
Acrylamide caused fiboadenomas in the mammary gland and benign tunica vaginalis mesotheliomas. Adenomas of the thyroid were observed in both sexes.
Carcinogenicity: via oral route (target organ): glandular: mammary gland; glandular: thyroids; urogenital: other
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